Evidence map›Paper›PMID 30091651›Full record

ArticleMolecular biology of the cell2018

The leucine-rich region of Flightless I interacts with R-ras to regulate cell extension formation.

P D Arora, T He, K Ng, C A McCulloch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

P D AroraMatrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 1A1, Canada.
T HeMatrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 1A1, Canada.
K NgMatrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 1A1, Canada.
C A McCullochMatrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 1A1, Canada.
University of Toronto · CA

Funding

CIHR MOP-36332
6 · The paper itself

Abstract

Flightless I (FliI) is a calcium-dependent, actin severing and capping protein that localizes to cell matrix adhesions, contributes to the generation of cell extensions, and colocalizes with Ras. Currently, the mechanism by which FliI interacts with Ras to enable assembly of actin-based cell protrusions is not defined. R-Ras, but not K-ras, H-ras, or N-ras, associated with the leucine-rich region (LRR) of FliI. Mutations of the proline-rich region of R-ras (P202A, P203A) prevented this association. Knockdown of Ras GTPase-activating SH3 domain-binding protein (G3BP1) or Rasgap

Indexed as

AnimalsCarrier ProteinsCattleCell Surface ExtensionsCollagenDNA HelicasesLeucineMiceMicrofilament ProteinsModels, BiologicalPoly-ADP-Ribose Binding ProteinsProtein Bindingras ProteinsRNA HelicasesRNA Recognition Motif ProteinsSignal TransductionCarrier ProteinsCollagenDNA HelicasesFlII protein, mouseG3bp1 protein, mouseLeucineMicrofilament ProteinsPoly-ADP-Ribose Binding Proteinsras ProteinsRNA HelicasesRNA Recognition Motif ProteinsRras protein, mouseTrans-Activators

Identifiers

PMID30091651
PMCPMC6233052
OpenAlexW2887533110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.