ArticleAddiction (Abingdon, England)2018
Independent predictors of mortality in adolescents ascertained for conduct disorder and substance use problems, their siblings and community controls.
Article in Addiction (Abingdon, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Directional associations between antisocial behavior and alcohol use disorder symptoms from adolescence through adulthood: A sibling comparison cross-lagged approach.Alcohol, clinical & experimental research · 2025Article
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- Adolescents with Elevated Psychopathic Traits are Associated with an Increased Risk for Premature Mortality.Research on child and adolescent psychopathology · 2025Article
- Subjective effects as predictors of substance use disorders in a clinical sample: A longitudinal study.Drug and alcohol dependence · 2023Article
- Evidence Base Update of Psychosocial Treatments for Adolescents with Disruptive Behavior.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2023Article
- An Examination of the 4 Rs 2 Ss for Problem Behaviors: A Preventive Approach.Families in society : the journal of contemporary human services · 2023Article
- Adolescents in Treatment for Substance Use Disorders: Callous-Unemotional Traits Moderate Associations Between Transdiagnostic Symptoms and Adolescent Suicidality.Child psychiatry and human development · 2023Article
- Structure and trends of externalizing and internalizing psychiatric symptoms and gender differences among adolescents in the US from 1991 to 2018.Social psychiatry and psychiatric epidemiology · 2022Article
- Co-occurring Mental Disorders in Transitional Aged Youth With Substance Use Disorders - A Narrative Review.Frontiers in psychiatry · 2022Review
- Incidence and comorbidities of disruptive behavior disorders diagnosed in Finnish specialist psychiatric services.Social psychiatry and psychiatric epidemiology · 2021Article
- Preliminary validity and reliability evidence of the Brief Antisocial Behavior Scale (B-ABS) in young adults from four countries.PloS one · 2021Article
- High Correspondence Between Child Behavior Checklist Rule Breaking Behavior Scale with Conduct Disorder in Males and Females.Child psychiatry and human development · 2020Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsAdolescents with conduct and substance use problems are at increased risk for premature mortality, but the extent to which these risk factors reflect family- or individual-level differences and account for shared or unique variance is unknown. This study examined common and independent contributions to mortality hazard in adolescents ascertained for conduct disorder (CD) and substance use disorder (SUD), their siblings and community controls, hypothesizing that individual differences in CD and SUD severity would explain unique variation in mortality risk beyond that due to clinical/control status and demographic factors.
designMortality analysis in a prospective study (Genetics of Antisocial Drug Dependence Study) that began in 1993.
settingMulti-site sample recruited in San Diego, California and Denver, Colorado, USA.
participantsA total of 1463 clinical probands were recruited through the juvenile correctional system, court-mandated substance abuse treatment programs and correctional schools, along with 1399 of their siblings, and 904 controls. MEASUREMENTS: Mortality and cause-of-death were assessed via National Death Index search (released October, 2017).
findingsThere were 104 deaths documented among 3766 (1168 female) adolescents and young adults (average age 16.79 years at assessment, 32.69 years at death/censoring). Mortality hazard for clinical probands and their siblings was 4.99 times greater than that of controls (95% confidence interval = 2.40-10.40; P < 0.001). After accounting for demographic characteristics, site, clinical status, familial dependence and shared contributions of CD and SUD, CD independently predicted mortality hazard, whereas SUD severity did not.
conclusionsIn the United States, youth with conduct and substance use disorders and their siblings face far greater risk of premature death than demographically similar community controls. In contrast to substance use disorder severity, conduct disorder is a robust predictor of unique variance in all-cause mortality hazard beyond other risk factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.