ReviewClinical research in cardiology : official journal of the German Cardiac Society2019
Subclinical hypothyroidism and the development of heart failure: an overview of risk and effects on cardiac function.
Review in Clinical research in cardiology : official journal of the German Cardiac Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Effect of thyroid hormone replacement treatment on cardiac diastolic function in adult patients with subclinical hypothyroidism: a meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Subclinical hypothyroidism and the risk of cancer incidence and cancer mortality: a systematic review.BMC endocrine disorders · 2020Pooled it
- Supplementation with selenium and coenzyme QBMC medicine · 2024Trial
- Hypothyroidism is associated with clinical outcomes in patients with acute myocardial infarction: subgroup analysis of China PEACE study.Endocrine · 2021Trial
- A risk assessment nomogram for cardiac remodeling in the multimorbid geriatric patients: a retrospective study.BMC geriatrics · 2026Article
- Preterm heart failure and refractory lactic acidosis caused by congenital hypothyroidism: A case report and review of literature.World journal of clinical cases · 2026Article
- Cardiomyopathies of endocrine origin: A state-of-the-art review.World journal of cardiology · 2025Review
- Subclinical hypothyroidism: a new predictor of heart failure with improved ejection fraction in HFrEF patients.Internal and emergency medicine · 2025Article
- Effect of thyroid stimulating hormone on the prognosis of coronary heart disease.Frontiers in endocrinology · 2025Article
- Association of Thyroid Dysfunction in Individuals ≥ 65 Years of Age With Subclinical Cardiac Abnormalities.The Journal of clinical endocrinology and metabolism · 2024Article
- Multi-omics insight into the metabolic and cellular characteristics in the pathogenesis of hypothyroidism.Communications biology · 2024Article
- The Role of Global Longitudinal Strain in Subclinical Hypothyroid Patients With Heart Failure.Cureus · 2023Article
- Transiently impaired endothelial function during thyroid hormone withdrawal in differentiated thyroid cancer patients.Frontiers in endocrinology · 2023Article
- Association of Elevated Thyroid Stimulating Hormone with Atherosclerotic Cardiovascular Disease and Its Mortality in Elderly Community-Dwelling Chinese.Clinical interventions in aging · 2022Article
- Angiopoietin-like proteins 3, 4 and 8 are linked to cardiovascular function in naïve sub-clinical and overt hypothyroid patients receiving levothyroxine therapy.Endocrine connections · 2021Article
- A practical contemporary approach to decision-making on subclinical hypothyroidism.Archives of endocrinology and metabolism · 2021Review
- Subclinical Hypothyroidism in Geriatric Population and Its Association With Heart Failure.Cureus · 2021Review
- Early L-T4 intervention improves fetal heart development in pregnant rats with subclinical hypothyroidism rats by activating BMP4/Smad4 signaling pathway.BMC cardiovascular disorders · 2020Article
- Hematological Indexes Can Be Used to Predict the Incidence of Hypothyroidism in Nasopharyngeal Carcinoma Patients after Radiotherapy.BioMed research international · 2020Article
- FABP4 levels in hypothyroidism and its relationship with subclinical atherosclerosisTurkish journal of medical sciences · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of subclinical hypothyroidism (SCH) ranges from 5 to 15% of the general population. However, it remains controversial if SCH warrants life-long thyroxine replacement therapy. Patients with a thyroid-stimulating hormone (TSH) level > 10 mIU/L have a higher risk of developing heart failure with reduced ejection fraction as compared to subjects with normal thyroid function. However, abnormally high TSH levels could also be connected with an overall lower metabolic rate and better survival in elderly subjects. The potential mechanisms responsible for diastolic dysfunction of the left ventricle (LV) in SCH are connected with endothelial dysfunction and arterial stiffness, inflammatory state and are driven by TSH apoptosis-derived microparticles. The impact of SCH on LV systolic function is more controversial, and it is connected not only with cardiac remodelling but also with predisposition of patients with SCH to the conditions leading to heart failure. This review presents an overview of processes in the context of potential benefits of thyroxine supplementation therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.