Evidence map›Paper›PMID 30091037›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2019

Simultaneous Serial Transverse Enteroplasty (STEP) in Size Mismatch Small Bowel Transplantations.

Giovanni Frongia, Ali Majlesara, Arash Saffari, Dezfouli Sepher Abbasi, Negin Gharabaghi, Jürgen Günther Okun, Christian Thiel, Patrick Günther, Rodrigo Vianna, Arianeb Mehrabi

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Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giovanni FrongiaDivision of Pediatric Surgery, Department of General, Visceral, and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany.
Ali MajlesaraDepartment of General, Visceral, and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany.
Arash SaffariDepartment of General, Visceral, and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany.
Dezfouli Sepher AbbasiDepartment of General, Visceral, and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany.
Negin GharabaghiDepartment of General, Visceral, and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany.
Jürgen Günther OkunDepartment of Pediatrics, Pediatric Metabolic Laboratory, University Hospital of Heidelberg, Heidelberg, Germany.
Christian ThielDepartment of Pediatrics, Pediatric Metabolic Laboratory, University Hospital of Heidelberg, Heidelberg, Germany.
Patrick GüntherDivision of Pediatric Surgery, Department of General, Visceral, and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany.
Rodrigo ViannaDivision of Liver/Gastrointestinal Transplantation, Miami Transplant Institute, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, FL, USA.
Arianeb MehrabiDepartment of General, Visceral, and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany. arianeb.mehrabi@med.uni-heidelberg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSmall bowel transplantation (SBTX) in children receiving larger grafts from adults can be challenging because of size mismatch. The aim of the present study was to assess whether a simultaneous serial transverse enteroplasty (STEP) can address the problem of size mismatch.

methodsThree different size ratio groups between donors and recipients were compared in a porcine model with a 14-day follow-up. The groups were size matched, size mismatched (1:3.8 weight ratio), and size mismatched + STEP (each n = 8).

resultsIt was technically feasible to simultaneously perform a STEP and SBTX of a mismatched intestinal segment. The postoperative clinical course was uneventful. No signs of bleeding, leakage, stenosis, or ileus were observed and the intestinal segment was well perfused at relaparotomy. Body weight decreased in all groups, but the percentage decrease was lowest in the mismatched + STEP group. Vital enterocyte masses were similar in all the groups (citrulline levels) and the nutritional status was best in the STEP group (transferrin levels, p = 0.04).

conclusionsWe have demonstrated that a simultaneous STEP and SBTX procedure is technically feasible and clinically useful in overcoming the challenges associated with size mismatched SBTX. Our short-term findings justify further investigation in a larger series to elucidate the long-term outcomes of this procedure.

Indexed as

AnimalsBody SizeDigestive System Surgical ProceduresFemaleIntestine, SmallNutritional StatusPlastic Surgery ProceduresPostoperative ComplicationsSwineTreatment OutcomeChildrenIntestinal transplantationLiving donorSize mismatchSTEP

Identifiers

PMID30091037

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.