ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2018
Morvan's syndrome-is a pathogen behind the curtain?
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Morvan syndrome in a patient with progressing metastatic thymoma and myasthenia gravis.BMJ case reports · 2026Article
- Morvan Fibrillary Chorea Associated with Monoclonal B Cell Lymphocytosis.The American journal of case reports · 2024Article
- Occult bowel cancer presenting as Morvan syndrome.BMJ case reports · 2023Article
- [Rare diseases in the differential diagnosis of myalgia].Schmerz (Berlin, Germany) · 2022Article
- CASPR2-Related Morvan Syndrome: Autonomic, Polysomnographic, and Neuropsychological Observations.Neurology. Clinical practice · 2021Article
- Morvan syndrome associated with LGI1 antibody: a case report.BMC neurology · 2021Article
- COVID-19 in India: Are Biological and Environmental Factors Helping to Stem the Incidence and Severity?Aging and disease · 2020Article
- A Patient with Double-Negative VGKC, Peripheral Nerve Hyperexcitability, and Central Nervous System Symptoms: A Postinfectious Autoimmune Disease.Case reports in neurological medicine · 2020Article
- Efficacy of Tocilizumab in Limbic Encephalitis with Anti-CASPR2 Antibodies.Case reports in neurological medicine · 2020Article
- Rare Diseases Day and Brain Awareness Week: the active participation of Neurological Sciences.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Morvan's syndrome treated successfully with rituximab and lacosamide.BMJ case reports · 2019Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morvan's syndrome is a rare syndrome of likely autoimmune etiology characterized by peripheral nerve hyperexcitability, dysautonomia, insomnia, and fluctuating delirium with prominent hallucinations. Since its first mention in 1890, less than 100 cases have been described in literature. The largest existing review includes details of 29 cases. This case series describes 4 cases (M = 4) of Morvan's syndrome which presented between May and November 2017 to a single tertiary care referral teaching hospital in north India. All the four patients manifested behavioral abnormalities, sleep disturbances, hallucinations, autonomic dysfunction, and clinical signs of peripheral nerve hyperexcitability, mostly as myokymia. Two of the patients had Anti-CASPR2 (contactin-associated protein 2) antibodies. Three of them had electromyography features of peripheral nerve hyperexcitability and only one had elevated cerebrospinal fluid protein level. We hypothesize that Morvan's syndrome and other less characterized autoimmune encephalitis/peripheral nervous system syndromes may have infectious triggers. A possible viral trigger may result in generation of autoantibodies which result in the typical manifestations. We base these hypotheses on the finding of four cases of an orphan disease within a short period of time in a limited geographical distribution.
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