ArticleNetwork neuroscience (Cambridge, Mass.)2018
High-energy brain dynamics during anesthesia-induced unconsciousness.
Article in Network neuroscience (Cambridge, Mass.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Estimating the energy of dissipative neural systems.Cognitive neurodynamics · 2024Article
- Characteristic dynamic functional connectivity during sevoflurane-induced general anesthesia.Scientific reports · 2023Article
- Analgesia for the Bayesian Brain: How Predictive Coding Offers Insights Into the Subjectivity of Pain.Current pain and headache reports · 2023Review
- Touchscreen-Based Cognitive Training Alters Functional Connectivity Patterns in Aged But Not Young Male Rats.eNeuro · 2023Article
- Characterization of Anesthesia in Rats from EEG in Terms of Long-Range Correlations.Diagnostics (Basel, Switzerland) · 2023Article
- Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane.Human brain mapping · 2021Article
- Metabolic Abnormalities in Patients with Chronic Disorders of Consciousness.Aging and disease · 2021Article
- Global Signal Topography of the Human Brain: A Novel Framework of Functional Connectivity for Psychological and Pathological Investigations.Frontiers in human neuroscience · 2021Review
- Geometric classification of brain network dynamics via conic derivative discriminants.Journal of neuroscience methods · 2018Article
- Impact of Total Knee Arthroplasty with General Anesthesia on Brain Networks: Cognitive Efficiency and Ventricular Volume Predict Functional Connectivity Decline in Older Adults.Journal of Alzheimer's disease : JAD · 2018Article
- Consciousness as a Physical Process Caused by the Organization of Energy in the Brain.Frontiers in psychology · 2018Article
- High-energy brain dynamics during anesthesia-induced unconsciousness.Network neuroscience (Cambridge, Mass.) · 2018Article
- Multiscale Imaging Reveals Aberrant Functional Connectome Organization and Elevated Dorsal StriataleNeuroArticle
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Authors and funding
3 authors.
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Abstract
Characterizing anesthesia-induced alterations to brain network dynamics provides a powerful framework to understand the neural mechanisms of unconsciousness. To this end, increased attention has been directed at how anesthetic drugs alter the functional connectivity between brain regions as defined through neuroimaging. However, the effects of anesthesia on temporal dynamics at functional network scales is less well understood. Here, we examine such dynamics in view of the free-energy principle, which postulates that brain dynamics tend to promote lower energy (more organized) states. We specifically engaged the hypothesis that such low-energy states play an important role in maintaining conscious awareness. To investigate this hypothesis, we analyzed resting-state BOLD fMRI data from human volunteers during wakefulness and under sevoflurane general anesthesia. Our approach, which extends an idea previously used in the characterization of neuron-scale populations, involves thresholding the BOLD time series and using a normalized Hamiltonian energy function derived from the Ising model. Our major finding is that the brain spends significantly more time in lower energy states during eyes-closed wakefulness than during general anesthesia. This effect is especially pronounced in networks thought to be critical for maintaining awareness, suggesting a crucial cognitive role for both the structure and the dynamical landscape of these networks.
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