ArticleComputational psychiatry (Cambridge, Mass.)2017
Computational Modeling of Contrast Sensitivity and Orientation Tuning in First-Episode and Chronic Schizophrenia.
Article in Computational psychiatry (Cambridge, Mass.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- The Relationship between Clinical and Psychophysical Assessments of Visual Perceptual Disturbances in Individuals at Clinical High Risk for Psychosis: A Preliminary Study.Brain sciences · 2024Article
- Stronger tilt aftereffects in individuals diagnosed with schizophrenia spectrum disorders but not bipolar disorder.Schizophrenia research · 2024Article
- A neural model of modified excitation/inhibition and feedback levels in schizophrenia.bioRxiv : the preprint server for biology · 2023Article
- Cognitive [Computational] Neuroscience Test Reliability and Clinical Applications for Serious Mental Illness (CNTRaCS) Consortium: Progress and Future Directions.Current topics in behavioral neurosciences · 2023Article
- A neural model of modified excitation/inhibition and feedback levels in schizophrenia.Frontiers in psychiatry · 2023Article
- Schizophrenia in Translation: Why the Eye?Schizophrenia bulletin · 2022Article
- Three prominent self-report risk measures show unique and overlapping utility in characterizing those at clinical high-risk for psychosis.Schizophrenia research · 2022Article
- Mathematical modeling of risk-taking in bipolar disorder: Evidence of reduced behavioral consistency, with altered loss aversion specific to those with history of substance use disorder.Computational psychiatry (Cambridge, Mass.) · 2022Article
- Pictorial size perception in schizophrenia.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2021Article
- The Imbalanced Plasticity Hypothesis of Schizophrenia-Related Psychosis: A Predictive Perspective.Cognitive, affective & behavioral neuroscience · 2021Review
- Perceptual Gains and Losses in Synesthesia and Schizophrenia.Schizophrenia bulletin · 2021Article
- Stronger tilt aftereffects in persons with schizophrenia.Journal of abnormal psychology · 2021Article
- The Phenomenology and Neurobiology of Visual Distortions and Hallucinations in Schizophrenia: An Update.Frontiers in psychiatry · 2021Review
- Schizophrenia and the retina: Towards a 2020 perspective.Schizophrenia research · 2020Article
- Absence of Excess Intra-Individual Variability in Retinal Function in People With Schizophrenia.Frontiers in psychiatry · 2020Article
- Development and Evaluation of a Visual Remediation Intervention for People with Schizophrenia.Journal of psychiatry and brain science · 2020Article
- Nonsocial and social cognition in schizophrenia: current evidence and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2019Article
- fMRI evidence of aberrant neural adaptation for objects in schizophrenia and bipolar disorder.Human brain mapping · 2019Article
- Hallucinations Beyond Voices: A Conceptual Review of the Phenomenology of Altered Perception in Psychosis.Schizophrenia bulletin · 2019Review
- Computational Modeling of Contrast Sensitivity and Orientation Tuning in First-Episode and Chronic Schizophrenia.Computational psychiatry (Cambridge, Mass.) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Computational modeling is a useful method for generating hypotheses about the contributions of impaired neurobiological mechanisms, and their interactions, to psychopathology. Modeling is being increasingly used to further our understanding of schizophrenia, but to date, it has not been applied to questions regarding the common perceptual disturbances in the disorder. In this article, we model aspects of low-level visual processing and demonstrate how this can lead to testable hypotheses about both the nature of visual abnormalities in schizophrenia and the relationships between the mechanisms underlying these disturbances and psychotic symptoms. Using a model that incorporates retinal, lateral geniculate nucleus (LGN), and V1 activity, as well as gain control in the LGN, homeostatic adaptation in V1, lateral excitation and inhibition in V1, and self-organization of synaptic weights based on Hebbian learning and divisive normalization, we show that (a) prior data indicating
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.