Evidence map›Paper›PMID 30090843›Full record

ArticleInternational journal of physical medicine & rehabilitation2018

Remission of Gilles de la Tourette Syndrome after Heat-Induced Dehydration.

James Robert Brašić, Zoltan Mari, Alicja Lerner, Vanessa Raymont, Eram Zaidi, Dean F Wong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of physical medicine & rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

James Robert BrašićDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Section of High Resolution Brain Positron Emission Tomography Imaging, Johns Hopkins Outpatient Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Zoltan MariDepartment of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, Maryland, USA.
Alicja LernerCenter for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland, USA.
Vanessa RaymontDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Section of High Resolution Brain Positron Emission Tomography Imaging, Johns Hopkins Outpatient Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Eram ZaidiDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Section of High Resolution Brain Positron Emission Tomography Imaging, Johns Hopkins Outpatient Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Dean F WongDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Section of High Resolution Brain Positron Emission Tomography Imaging, Johns Hopkins Outpatient Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins Medicine · USJohns Hopkins University · USCenter for Drug Evaluation and Research · USJohns Hopkins Hospital · US

Funding

ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FLEXNER, CHARLES W. · 1985 to 2007
$37.3M
Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI FATEMI, S. ALI · 2014 to 2019
$7.9M
IMAGING DOPAMINE RELEASE/ENDOCRINE CHANGES IN ALCOHOLISMR01AA012839 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI WONG, DEAN FOSTER · 2000 to 2004
$3.7M
Mechanisms of Dopamine and Serotonin in Tourette SyndromeR01MH078175 · NIMH · JOHNS HOPKINS UNIVERSITY · PI WONG, DEAN FOSTER · 2006 to 2011
$3.0M
IMAGING RESEARCH IN NEUROPSYCHIATRY AND DRUG ABUSEK24DA000412 · NIDA · JOHNS HOPKINS UNIVERSITY · PI WONG, DEAN FOSTER · 2000 to 2009
$1.5M
MECHANISMS OF DOPAMINE &SEROTONIN IN TOURETTE SYNDROMER01NS038927 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WONG, DEAN FOSTER · 2001 to 2003
$1.4M
NCRR NIH HHS M01 RR000052NIAAA NIH HHS R01 AA012839NICHD NIH HHS U54 HD079123NIDA NIH HHS K24 DA000412NIMH NIH HHS R01 MH078175NINDS NIH HHS R01 NS038927
6 · The paper itself

Abstract

Heat has been reported to exert variable effects on people with Gilles de la Tourette syndrome (TS). At age 24 years, a 32-year-old right-handed man with TS experienced a marked reduction in tics for two years after undergoing dehydration by entering a hot tub at 103°F (39.4°C) to 104°F (40.0°C) for 3 to 4 hours. On the Yale Global Tic Severity Scale (YGTSS) he scored 55 seven months before dehydration and 13 one month after dehydration. An intense heat exposure and dehydration led to an apparent remission in tics. The remission continued without the use of prescribed or nonprescribed medications or substances for two years until tics returned in the worst ever exacerbation after a tetanus immunization. The heat exposure may have altered at least temporarily his thermostat for normal heat-loss mechanisms through dopaminergic pathways from the anterior hypothalamus to the basal ganglia and the substantia nigra. Whether or not that mechanism or some other mechanism relevant to the heat exposure and/or dehydration is at play, the sudden and marked improvement in his tics needs further attention. Prospective testing of the heat and dehydration effect on tics should be pursued.

Indexed as

Basal gangliaDopamineHypothalamusSubstantia nigraThermoregulationThermostatTics

Identifiers

PMID30090843
PMCPMC6078428
OpenAlexW2879416554

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.