ArticleBulletin of emergency and trauma2018
The Effects of Chicken Embryo Brain Extract on Sciatic Nerve Regeneration of Male Rat; An Experimental Study.
Article in Bulletin of emergency and trauma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors at 3 institutions in 1 country.
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Abstract
objectiveTo determine the effects of chicken embryo brain extract (BE) on transects sciatic nerve in male rats.
methodsThirty adult male Sprague-Dawley rats weighing 200 to 250 g, were randomized into three groups treated with (1) sham surgery, (2) normal saline (NS), and (3) brain extract (BE). The BE was taken from incubating chick embryos at day 8. The sciatic nerve was exposed and sharply transected at the mid thigh level. Immediate epineurial repair was then performed. The BE treated animals were given 400 µl/kg of the chick embryo BE intraperitoneal, once daily, for 2 weeks. All animals were evaluated by sciatic functional index (SFI), electrophysiology, histology, and immunohistochemistry at days 28, 90 after surgery.
resultsThe mean SFI difference between BE and NS groups at days 28, 60 and 90 after surgery was statistically significant (
conclusionThese results indicate for the first time that chick embryo brain extract can enhance peripheral nerve regeneration in rat.
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