Evidence map›Paper›PMID 30090697›Full record

Trial reportNeuroImage. Clinical2018

Changes in electrophysiological markers of cognitive control after administration of galantamine.

Lauren E Gascoyne, Karen J Mullinger, Siân E Robson, Jyothika Kumar, George C O'Neill, Lena Palaniyappan, Peter G Morris, Elizabeth B Liddle, Matthew J Brookes, Peter F Liddle

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Lauren E GascoyneSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK. Electronic address: lauren.gascoyne@nottingham.ac.uk.
Karen J MullingerSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.
Siân E RobsonSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.
Jyothika KumarInstitute of Mental Health, Jubilee Campus, University of Nottingham, Nottingham, UK.
George C O'NeillSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.
Lena PalaniyappanDepartment of Psychiatry & Robarts Research Institute, University of Western Ontario & Lawson Health Research Institute, London, ON, Canada.
Peter G MorrisSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.
Elizabeth B LiddleInstitute of Mental Health, Jubilee Campus, University of Nottingham, Nottingham, UK.
Matthew J BrookesSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.
Peter F LiddleInstitute of Mental Health, Jubilee Campus, University of Nottingham, Nottingham, UK. Electronic address: peter.liddle@nottingham.ac.uk.
University of Nottingham · GBWestern University · CA

Funding

Medical Research Council MR/J01186X/1
6 · The paper itself

Abstract

The healthy brain is able to maintain a stable balance between bottom-up sensory processing and top-down cognitive control. The neurotransmitter acetylcholine plays a substantial role in this. Disruption of this balance could contribute to symptoms occurring in psychosis, including subtle disruption of motor control and aberrant appropriation of salience to external stimuli; however the pathological mechanisms are poorly understood. On account of the role beta oscillations play in mediating cognitive control, investigation of beta oscillations is potentially informative about such mechanisms. Here, we used magnetoencephalography to investigate the effect of the acetylcholinesterase-inhibitor, galantamine, on beta oscillations within the sensorimotor region during both a sensorimotor task and a relevance-modulation task in healthy participants, employing a double blind randomized placebo controlled cross-over design. In the galantamine condition, we found a significant reduction in the post-movement beta rebound in the case of executed movements and also in a planned but not executed movement. In the latter case, the effect was significantly greater following task-relevant compared with irrelevant stimuli. The results suggest that the action of galantamine reduces the influence of top-down cognitive processing relative to bottom-up perceptual processing in a manner resembling changes previously reported in schizophrenia.

Indexed as

AdultBeta RhythmBrainCognitionDouble-Blind MethodElectrophysiological PhenomenaFemaleGalantamineHumansMaleNootropic AgentsPhotic StimulationPsychomotor PerformanceSchizophreniaSchizophrenic PsychologyYoung AdultGalantamineNootropic AgentsAcetylcholineBeta oscillationsMagnetoencephalographyPMBRSchizophrenia

Identifiers

PMID30090697
PMCPMC6078055
OpenAlexW2884716317

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.