ArticleToxicology research2018
The systemic toxicity of heavy metal mixtures in rats.
Article in Toxicology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 80 citations in OpenAlex.
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- Upcycling Coir Fiber into Polydopamine-Enabled Adsorbents for Efficient Cu(II)/Cd(II) Removal and Effluent Safety.Materials (Basel, Switzerland) · 2026Article
- Heavy Metals and Polycyclic Aromatic Hydrocarbons Levels in Selected Occupational and Environmental Settings in Liberia: A Systematic Review.Environmental health insights · 2026Review
- Cadmium toxicity alleviation in rats using lactobacillus-fermented and unfermented opuntia ficus-indica L. juices.Toxicology reports · 2025Article
- Role ofAntioxidants (Basel, Switzerland) · 2024Article
- Evaluation of the cognitive, physiological, and biomarker effects of heavy metal exposure in Wistar rats.Veterinary world · 2024Article
- Association and mediation analyses among multiple metal exposure, mineralocorticoid levels, and serum ion balance in residents of northwest China.Scientific reports · 2024Article
- Ecotoxicological impacts of industrial effluents on irrigation water quality, animal health and the role of calcium alginate in effluents treatment.Environmental monitoring and assessment · 2022Article
- Developmental Toxicology of Metal Mixtures inInternational journal of molecular sciences · 2021Article
- Element transfer by a vapor-gas stream from sulfide mine tailings: from field and laboratory evidence to thermodynamic modeling.Environmental science and pollution research international · 2021Article
- Standardized experimental model for cement dust exposure; tissue heavy metal bioaccumulation and pulmonary pathological changes in rats.Toxicology reports · 2021Article
- Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development.Cells · 2020Review
- Protective Effect ofJournal of toxicology · 2020Article
- Concentrations of toxic metals and essential trace elements vary among individual neurons in the human locus ceruleus.PloS one · 2020Article
- Outcomes and Toxicology of Herbal Drugs in Alcoholic Hepatitis - A Single Center Experience from India.Journal of clinical and translational hepatology · 2019Article
- Pollution and Perceptions of Lead in Automobile Repair Shops in Dhaka, Bangladesh.Journal of health & pollution · 2019Article
- Review
- Exploring the binding interaction between copper ions and Candida rugosa lipase.Toxicology research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To explore the health effects of multi-heavy metal exposure, Sprague Dawley (SD) rats were orally given one dose of heavy metal mixtures (HMMs). The eight most common detectable heavy metals in Ningbo area are zinc (Zn), copper (Cu), manganese (Mn), chromium (Cr), nickel (Ni), cadmium (Cd), lead (Pb) and mercury (Hg). In this study, mixtures of these eight heavy metals were prepared using the compounds zinc sulfate heptahydrate, cupric sulfate, manganese dichloride, potassium dichromate, nickel dichloride, cadmium dichloride, lead acetate, and methyl mercury chloride with ion mass proportions of 1070.0, 312.6, 173.1, 82.6, 30.0, 13.3, 6.6, and 1.0, respectively. The rats were randomly divided into four groups. Beside the control group, each rat received a corresponding dose of HMMs 215, 464 or 1000 mg per kg body weight (bwt), respectively. The rats were observed for 4 weeks. During the last week of observation, the Morris water maze test was used to investigate spatial learning and memory in the treated rats. The rats were exsanguinated under complete chloral hydrate anesthesia and organ coefficients were measured. Biochemical tests of blood and serum samples were carried out. The results showed abnormalities in the hematological system, decreased renal function, hepatic injury and disturbances in the electrolyte balance of the rats treated with a high dose of HMMs. Death of some rats was also observed. This paper analyzed how a one-time high dose oral administration of HMMs induced systemic toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.