Evidence map›Paper›PMID 30090569›Full record

ArticleToxicology research2018

Identification of the Al-binding proteins that account for aluminum neurotoxicity and transport

Dai Cheng, Xiaomei Wang, Yu Xi, Jiankang Cao, Weibo Jiang

Open access · bronzeAbstract read
In one paragraph

Article in Toxicology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Dai ChengKey Laboratory of Food Safety and Sanitation , Ministry of Education , College of Food Engineering and Biotechnology , Tianjin University of Science and Technology , Tianjin , People's Republic of China.ORCID 0000-0002-4956-948X
Xiaomei WangCollege of Food Science and Nutritional Engineering , China Agricultural University , Beijing , People's Republic of China . Email: jwb@cau.edu.cn.
Yu XiCollege of Food Science and Nutritional Engineering , China Agricultural University , Beijing , People's Republic of China . Email: jwb@cau.edu.cn.
Jiankang CaoCollege of Food Science and Nutritional Engineering , China Agricultural University , Beijing , People's Republic of China . Email: jwb@cau.edu.cn.
Weibo JiangCollege of Food Science and Nutritional Engineering , China Agricultural University , Beijing , People's Republic of China . Email: jwb@cau.edu.cn.ORCID 0000-0002-2445-0001
State Council of the People's Republic of China · CNTianjin University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies have shown that aluminum (Al) is the most abundant neurotoxic element on Earth, and is implicated in the pathogenesis of Alzheimer's disease (AD). However, the mechanisms underlying Al-induced neurotoxicity are still largely elusive. Based on affinity analyses with Al and LC-LTQ-MS, we have found that serum albumin, brain CK-B and 14-3-3ζ protein have a high affinity for Al

Identifiers

PMID30090569
PMCPMC6062109
OpenAlexW2773184797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.