Evidence map›Paper›PMID 30090529›Full record

ArticleToxicology research2017

Chronic high-dosage fish oil exacerbates gut-liver axis injury in alcoholic steatohepatitis in mice: the roles of endotoxin and IL-4 in Kupffer cell polarization imbalance.

Xiao-Jun Li, Yun-Mei Mu, Qiu-Fang Qin, Zi-Xuan Zeng, Yu-Sang Li, Wei Kevin Zhang, He-Bin Tang, Gui-Hua Tian, Hong-Cai Shang

Open access · bronzeAbstract read
In one paragraph

Article in Toxicology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. [Establishment and optimization of hepatocyte steatosis model].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Xiao-Jun LiDepartment of Pharmacology , School of Pharmaceutical Sciences , South-Central University for Nationalities , No. 182 Minyuan Road , 430074 , Wuhan , China . Email: hbtang2006@mail.scuec.edu.cn ; ; Tel: +86 27 6784 2332.
Yun-Mei MuDepartment of Pharmacology , School of Pharmaceutical Sciences , South-Central University for Nationalities , No. 182 Minyuan Road , 430074 , Wuhan , China . Email: hbtang2006@mail.scuec.edu.cn ; ; Tel: +86 27 6784 2332.
Qiu-Fang QinDepartment of Pharmacology , School of Pharmaceutical Sciences , South-Central University for Nationalities , No. 182 Minyuan Road , 430074 , Wuhan , China . Email: hbtang2006@mail.scuec.edu.cn ; ; Tel: +86 27 6784 2332.
Zi-Xuan ZengDepartment of Pharmacology , School of Pharmaceutical Sciences , South-Central University for Nationalities , No. 182 Minyuan Road , 430074 , Wuhan , China . Email: hbtang2006@mail.scuec.edu.cn ; ; Tel: +86 27 6784 2332.
Yu-Sang LiDepartment of Pharmacology , School of Pharmaceutical Sciences , South-Central University for Nationalities , No. 182 Minyuan Road , 430074 , Wuhan , China . Email: hbtang2006@mail.scuec.edu.cn ; ; Tel: +86 27 6784 2332.ORCID 0000-0002-7508-0469
Wei Kevin ZhangDepartment of Pharmacology , School of Pharmaceutical Sciences , South-Central University for Nationalities , No. 182 Minyuan Road , 430074 , Wuhan , China . Email: hbtang2006@mail.scuec.edu.cn ; ; Tel: +86 27 6784 2332.
He-Bin TangDepartment of Pharmacology , School of Pharmaceutical Sciences , South-Central University for Nationalities , No. 182 Minyuan Road , 430074 , Wuhan , China . Email: hbtang2006@mail.scuec.edu.cn ; ; Tel: +86 27 6784 2332.ORCID 0000-0002-2673-7882
Gui-Hua TianKey Laboratory of Chinese Internal Medicine of MOE and Beijing , Dongzhimen Hospital , Beijing University of Chinese Medicine , 100029 , Beijing , China . Email: shanghongcai@126.com ; ; Tel: +86 10 8401 2510.
Hong-Cai ShangKey Laboratory of Chinese Internal Medicine of MOE and Beijing , Dongzhimen Hospital , Beijing University of Chinese Medicine , 100029 , Beijing , China . Email: shanghongcai@126.com ; ; Tel: +86 10 8401 2510.
South Central Minzu University · CNBeijing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, intestinal tight junctions (TJs) and Kupffer cell polarization were investigated in an alcoholic steatohepatitis (ASH) mouse model to uncover the potential side effects of overexposure to fish oil or omega-3 fatty acids. The mice were fed

Identifiers

PMID30090529
PMCPMC6062209
OpenAlexW2733755050

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.