Evidence map›Paper›PMID 30090523›Full record

ArticleToxicology research2017

A comparison of toxicity and toxicokinetics in rats and dogs following twenty-eight-day, repeat-dose oral administration of nifurtimox.

Ye Li, Tian-Tian Liu, Hong-Tao Jin, Piao-Piao Zhang, Dan Qin, Qian-Qian Zhang, Wen-Tao Wu, Cui-Ping Yang, Ai-Ping Wang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Ye LiNew Drug Safety Evaluation Center , Institute of Materia Medica , Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China 100050 . Email: yangcp@imm.ac.cn ; Email: wangaiping@imm.ac.cn.ORCID 0000-0003-1085-8249
Tian-Tian LiuNew Drug Safety Evaluation Center , Institute of Materia Medica , Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China 100050 . Email: yangcp@imm.ac.cn ; Email: wangaiping@imm.ac.cn.
Hong-Tao JinNew Drug Safety Evaluation Center , Institute of Materia Medica , Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China 100050 . Email: yangcp@imm.ac.cn ; Email: wangaiping@imm.ac.cn.
Piao-Piao ZhangNew Drug Safety Evaluation Center , Institute of Materia Medica , Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China 100050 . Email: yangcp@imm.ac.cn ; Email: wangaiping@imm.ac.cn.
Dan QinNew Drug Safety Evaluation Center , Institute of Materia Medica , Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China 100050 . Email: yangcp@imm.ac.cn ; Email: wangaiping@imm.ac.cn.
Qian-Qian ZhangNew Drug Safety Evaluation Center , Institute of Materia Medica , Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China 100050 . Email: yangcp@imm.ac.cn ; Email: wangaiping@imm.ac.cn.
Wen-Tao WuHengtaijiukang Pharmaceutical Technology Co. , Ltd , Tianjin , China 300384.
Cui-Ping YangNew Drug Safety Evaluation Center , Institute of Materia Medica , Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China 100050 . Email: yangcp@imm.ac.cn ; Email: wangaiping@imm.ac.cn.
Ai-Ping WangNew Drug Safety Evaluation Center , Institute of Materia Medica , Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China 100050 . Email: yangcp@imm.ac.cn ; Email: wangaiping@imm.ac.cn.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNBeijing Union University · CNBuchang Pharma (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nifurtimox has been an important treatment for trypanosomiasis for many years, but new research indicates that the drug may also be an effective therapy for malignant neuroblastoma. However, there have been few published reports evaluating the toxicity of nifurtimox in different species. Therefore, to further understand its toxicity and toxicokinetic profiles, Sprague Dawley rats and beagle dogs were orally administered nifurtimox at 0, 25, 75 and 150 mg kg

Identifiers

PMID30090523
PMCPMC6062185
OpenAlexW2616104962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.