Evidence map›Paper›PMID 30090515›Full record

ArticleToxicology research2017

ATF2 partly mediated the expressions of proliferative factors and inhibited pro-inflammatory factors' secretion in arsenite-treated human uroepithelial cells.

Shengnan Liu, Fei Wang, Jieyu Liu, Peiyu Jin, Xiaoyan Wang, Li Yang, Shuhua Xi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Arsenic Impairs Wound Healing Processes in Dermal Fibroblasts and Mice.International journal of molecular sciences · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shengnan LiuDepartment of Environmental and Occupational Health , School of Public Health , China Medical University , No. 77 Puhe Road , Shenyang North New Area , Shenyang , Liaoning Province 110122 , People's Republic of China . Email: shxi@cmu.edu.cn.
Fei WangDepartment of Environmental and Occupational Health , School of Public Health , China Medical University , No. 77 Puhe Road , Shenyang North New Area , Shenyang , Liaoning Province 110122 , People's Republic of China . Email: shxi@cmu.edu.cn.
Jieyu LiuDepartment of Environmental and Occupational Health , School of Public Health , China Medical University , No. 77 Puhe Road , Shenyang North New Area , Shenyang , Liaoning Province 110122 , People's Republic of China . Email: shxi@cmu.edu.cn.
Peiyu JinDepartment of Environmental and Occupational Health , School of Public Health , China Medical University , No. 77 Puhe Road , Shenyang North New Area , Shenyang , Liaoning Province 110122 , People's Republic of China . Email: shxi@cmu.edu.cn.
Xiaoyan WangDepartment of Environmental and Occupational Health , School of Public Health , China Medical University , No. 77 Puhe Road , Shenyang North New Area , Shenyang , Liaoning Province 110122 , People's Republic of China . Email: shxi@cmu.edu.cn.
Li YangDepartment of Environmental and Occupational Health , School of Public Health , China Medical University , No. 77 Puhe Road , Shenyang North New Area , Shenyang , Liaoning Province 110122 , People's Republic of China . Email: shxi@cmu.edu.cn.
Shuhua XiDepartment of Environmental and Occupational Health , School of Public Health , China Medical University , No. 77 Puhe Road , Shenyang North New Area , Shenyang , Liaoning Province 110122 , People's Republic of China . Email: shxi@cmu.edu.cn.ORCID 0000-0003-4232-7258
State Council of the People's Republic of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inorganic arsenic (iAs) could induce the expression of activating transcription factor-2 (ATF2) in the human urinary bladder epithelial cell line (SV-HUC-1 cells). ATF2, as a member of the bZIP transcription factor family, has been implicated in a transcriptional response leading to cell growth, migration and malignant tumor progression. However, little is known about the effects of ATF2 on proliferative factors in iAs treated human urothelial cells. In this study, ATF2 siRNA was employed to investigate the relationship between ATF2 activation and the expressions of proliferative factors, such as BCL2, cyclin D1, COX-2, MMP1 and PCNA, and pro-inflammatory factors (TNFα, TGFα and IL-8) in SV-HUC-1 cells. The results showed that low concentration arsenite increased the expressions of proliferative factors BCL2, cyclin D1, COX-2, MMP1 and PCNA in SV-HUC-1 cells, and ATF2 siRNA partly decreased the expressions of BCL2, cyclin D1, and COX-2. A neutralizing antibody of IL-8 was used for attenuating the levels of IL-8 and neutralizing antibody of IL-8 did not relieve the expressions of ATF2 and proliferative factors induced by arsenite in SV-HUC-1 cells. In addition, ATF2 knockdown did not decrease the expressions of pro-inflammatory cytokines induced by arsenite in SV-HUC-1 cells, but dramatically increased mRNA expressions of TNFα, TGFα and IL-8 under arsenite and non-arsenite conditions. In conclusion, our present study indicated that ATF2, but not IL-8, played a partial role in the expressions of proliferative factors induced by arsenite in human uroepithelial cells.

Identifiers

PMID30090515
PMCPMC6062379
OpenAlexW2597435472

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.