Evidence map›Paper›PMID 30090463›Full record

ArticleToxicology research2016

Hydroxylated-graphene quantum dots induce cells senescence in both p53-dependent and -independent manner.

Xin Tian, Bei-Bei Xiao, Anqing Wu, Lan Yu, Jundong Zhou, Yu Wang, Nan Wang, Hua Guan, Zeng-Fu Shang

Abstract read
In one paragraph

Article in Toxicology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Toxicity of Zero- and One-Dimensional Carbon Nanomaterials.Nanomaterials (Basel, Switzerland) · 2019
    Review
  7. Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xin TianSchool of Radiation Medicine and Protection , Medical College of Soochow University , Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Suzhou , Jiangsu 215123 , P.R. China . Email: zengfu.shang@suda.edu.cn.
Bei-Bei XiaoSchool of Radiation Medicine and Protection , Medical College of Soochow University , Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Suzhou , Jiangsu 215123 , P.R. China . Email: zengfu.shang@suda.edu.cn.
Anqing WuSchool of Radiation Medicine and Protection , Medical College of Soochow University , Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Suzhou , Jiangsu 215123 , P.R. China . Email: zengfu.shang@suda.edu.cn.
Lan YuDivision of Molecular Radiation Biology , Department of Radiation Oncology , University of Texas Southwestern Medical Center at Dallas , Dallas , Texas 75390 , USA.
Jundong ZhouSuzhou Cancer Center Core Laboratory , Nanjing Medical University Affiliated Suzhou Hospital , Suzhou , Jiangsu 215001 , P.R. China.
Yu WangDepartment of Radiation Toxicology and Oncology , Beijing Key Laboratory for Radiobiology (BKLRB) , Beijing Institute of Radiation Medicine , Beijing 100850 , P. R. China . Email: ghlsh@163.com.
Nan WangSchool of Radiation Medicine and Protection , Medical College of Soochow University , Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Suzhou , Jiangsu 215123 , P.R. China . Email: zengfu.shang@suda.edu.cn.
Hua GuanDepartment of Radiation Toxicology and Oncology , Beijing Key Laboratory for Radiobiology (BKLRB) , Beijing Institute of Radiation Medicine , Beijing 100850 , P. R. China . Email: ghlsh@163.com.
Zeng-Fu ShangSchool of Radiation Medicine and Protection , Medical College of Soochow University , Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Suzhou , Jiangsu 215123 , P.R. China . Email: zengfu.shang@suda.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The numerous particular chemical/physical properties make graphene quantum dots (GQDs) attractive for various biomedical applications such as drug delivery, bioimaging and tumor photodynamic therapy (PDT). In the present study, the critical roles of hydroxyl-modified GQDs (OH-GQDs) on lung carcinoma A549 (wild type p53) and H1299 (p53-null) cells were investigated. Our data showed that a medium concentration (50 μg mL

Identifiers

PMID30090463
PMCPMC6061981

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.