Evidence map›Paper›PMID 30090452›Full record

ArticleToxicology research2016

Adenosine diphosphate involvement in THP-1 maturation triggered by the contact allergen 1-fluoro-2,4-dinitrobenzene.

J D Martins, A Silva, I Ferreira, M Gonçalo, J B A Custódio, M C Lopes, M R M Domingues, B M Neves, M T Cruz

Open access · bronzeAbstract read
In one paragraph

Article in Toxicology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

J D MartinsFaculty of Pharmacy University of Coimbra , 3000-548 Coimbra , Portugal . Email: jdmartins@oninet.pt ; Email: trosete@ff.uc.pt ; ; Tel: +351 239 480 209.
A SilvaCNC - Center for Neuroscience and Cell Biology , University of Coimbra , 3004-517 Coimbra , Portugal.
I FerreiraCNC - Center for Neuroscience and Cell Biology , University of Coimbra , 3004-517 Coimbra , Portugal.
M GonçaloDepartment of Dermatology , University Hospital and Faculty of Medicine , University of Coimbra , 3000-075 Coimbra , Portugal.
J B A CustódioFaculty of Pharmacy University of Coimbra , 3000-548 Coimbra , Portugal . Email: jdmartins@oninet.pt ; Email: trosete@ff.uc.pt ; ; Tel: +351 239 480 209.
M C LopesFaculty of Pharmacy University of Coimbra , 3000-548 Coimbra , Portugal . Email: jdmartins@oninet.pt ; Email: trosete@ff.uc.pt ; ; Tel: +351 239 480 209.
M R M DominguesDepartment of Chemistry , Mass Spectrometry Center , QOPNA , University of Aveiro , Campus Universitário de Santiago , 3810-193 Aveiro , Portugal.
B M NevesFaculty of Pharmacy University of Coimbra , 3000-548 Coimbra , Portugal . Email: jdmartins@oninet.pt ; Email: trosete@ff.uc.pt ; ; Tel: +351 239 480 209.
M T CruzFaculty of Pharmacy University of Coimbra , 3000-548 Coimbra , Portugal . Email: jdmartins@oninet.pt ; Email: trosete@ff.uc.pt ; ; Tel: +351 239 480 209.
Institut des Sciences Cognitives Marc Jeannerod · FRUniversity of Coimbra · PTUniversity Hospital · CAUniversity of Aveiro · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells' (DC) activation is considered a key event in the adverse outcome pathway for skin sensitization elicited by covalent binding of chemicals to proteins. The mechanisms underlying DC activation by contact sensitizers are not completely understood. However, several "danger signals" are pointed as relevant effectors. Among these extra-cellular early danger signals, purines may be crucial for the development of

Identifiers

PMID30090452
PMCPMC6060794
OpenAlexW2480031481

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.