ArticleToxicology research2016
Modifications of H3K9me2, H3K36me3 and H4K20me2 may be involved in arsenic-induced genetic damage.
Article in Toxicology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Toxicology of Airborne Inorganic Arsenic: Oxidative Stress, Molecular Mechanisms, and Organ-Specific Pathologies.Toxics · 2025Review
- Arsenic toxicity: sources, pathophysiology and mechanism.Toxicology research · 2024Review
- Histone post-translational modification and the DNA damage response.Genes & diseases · 2023Review
- Arsenic and cancer: Evidence and mechanisms.Advances in pharmacology (San Diego, Calif.) · 2023Article
- Article
- The role of PSMB5 in sodium arsenite-induced oxidative stress in L-02 cells.Cell stress & chaperones · 2020Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endemic arsenic poisoning is a worldwide disease and many studies show that arsenic has obvious genetic toxicity. However, the mechanism of arsenic-induced genetic damage is unclear. In this study, coal-fired arsenic poisoning patients in the Guizhou Province, China, were selected as research subjects. Through an analysis of the relationship between genetic damage and histone modification levels and by comparing the control and arsenic poisoning groups, further analysis of their relationship was carried out, the aim being to explore the role of histone modification in arsenic-induced genetic damage. The result shows that arsenic may inhibit the modification level of H4K20me2 and H3K9me2, and increase the modification of H3K36me3, involved in the repair of DNA damage induced by arsenic. This study could provide a new pathway for studies of the genetic toxicity of arsenic.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.