Evidence map›Paper›PMID 30090429›Full record

ArticleToxicology research2016

Counter ions and constituents combination affect DODAX : MO nanocarriers toxicity

Ana Cristina Norberto Oliveira, Marisa Passos Sárria, Pedro Moreira, Joana Fernandes, Lisandra Castro, Ivo Lopes, Manuela Côrte-Real, Artur Cavaco-Paulo, Maria Elisabete Cunha Dias Real Oliveira, Andreia Castro Gomes

Open access · bronzeAbstract read
In one paragraph

Article in Toxicology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Ana Cristina Norberto OliveiraCBMA (Center of Molecular and Environmental Biology) , Department of Biology , University of Minho , Campus of Gualtar , 4710 057 Braga , Portugal . Email: agomes@bio.uminho.pt ; ; Tel: +351 253 601 511.
Marisa Passos SárriaINL - International Iberian Nanotechnology Laboratory , Av. Mestre José Veiga , 4715-330 Braga , Portugal.
Pedro MoreiraCBMA (Center of Molecular and Environmental Biology) , Department of Biology , University of Minho , Campus of Gualtar , 4710 057 Braga , Portugal . Email: agomes@bio.uminho.pt ; ; Tel: +351 253 601 511.
Joana FernandesCBMA (Center of Molecular and Environmental Biology) , Department of Biology , University of Minho , Campus of Gualtar , 4710 057 Braga , Portugal . Email: agomes@bio.uminho.pt ; ; Tel: +351 253 601 511.
Lisandra CastroCBMA (Center of Molecular and Environmental Biology) , Department of Biology , University of Minho , Campus of Gualtar , 4710 057 Braga , Portugal . Email: agomes@bio.uminho.pt ; ; Tel: +351 253 601 511.
Ivo LopesCBMA (Center of Molecular and Environmental Biology) , Department of Biology , University of Minho , Campus of Gualtar , 4710 057 Braga , Portugal . Email: agomes@bio.uminho.pt ; ; Tel: +351 253 601 511.
Manuela Côrte-RealCBMA (Center of Molecular and Environmental Biology) , Department of Biology , University of Minho , Campus of Gualtar , 4710 057 Braga , Portugal . Email: agomes@bio.uminho.pt ; ; Tel: +351 253 601 511.
Artur Cavaco-PauloCEB , Department of Biological Engineering , University of Minho , Campus of Gualtar , 4710-057 Braga , Portugal.ORCID 0000-0001-7204-2064
Maria Elisabete Cunha Dias Real OliveiraCFUM (Center of Physics) , Department of Physics , University of Minho , Campus of Gualtar , 4710-057 Braga , Portugal.
Andreia Castro GomesCBMA (Center of Molecular and Environmental Biology) , Department of Biology , University of Minho , Campus of Gualtar , 4710 057 Braga , Portugal . Email: agomes@bio.uminho.pt ; ; Tel: +351 253 601 511.
MRC Laboratory of Molecular Biology · GBCentre de Physique Théorique · FRCorporate Executive Board (United States) · USInternational Iberian Nanotechnology Laboratory · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liposomes have received extensive attention as nanocarriers for bioactive compounds due to their good biocompatibility, possibility of targeting and incorporation of hydrophilic and hydrophobic compounds. Although generally considered as safe, detailed knowledge of the effects induced in cells and tissues with which they interact is still underexplored. The aim of this study is to gain insight into the toxicity profile of dioctadecyldimethylammonium (DODAX) : monoolein(MO) liposomes (X is bromide or chloride), previously validated for gene therapy, by evaluating the effect of the counter ions Br

Identifiers

PMID30090429
PMCPMC6062248
OpenAlexW2419982124

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.