ArticleToxicology research2016
Cytotoxicity and autophagy dysfunction induced by different sizes of silica particles in human bronchial epithelial BEAS-2B cells.
Article in Toxicology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- The Size-dependent Cytotoxicity of Amorphous Silica Nanoparticles: A Systematic Review of in vitro Studies.International journal of nanomedicine · 2020Pooled it
- New approach methodologies for in vitro toxicity screening of nanomaterial using a pulmonary three-dimensional floating extracellular matrix model.Journal of biological engineering · 2025Article
- Health burden of sugarcane burning on agricultural workers and nearby communities.Inhalation toxicology · 2024Review
- Profiling of metabolites, proteins, and protein phosphorylation in silica-exposed BEAS-2B epithelial cells.PloS one · 2023Article
- Autophagy-mediated nanomaterials for tumor therapy.Frontiers in oncology · 2023Review
- An integrative multi-omics approach uncovers the regulatory role of CDK7 and CDK4 in autophagy activation induced by silica nanoparticles.Autophagy · 2021Article
- Mechanical cues protect against silica nanoparticle exposure in SH-SY5Y neuroblastoma.Toxicology in vitro : an international journal published in association with BIBRA · 2021Article
- Predicting Cytotoxicity of Metal Oxide Nanoparticles using Isalos Analytics Platform.Nanomaterials (Basel, Switzerland) · 2020Article
- Low-Dose Exposure of Silica Nanoparticles Induces Neurotoxicity via Neuroactive Ligand-Receptor Interaction Signaling Pathway in Zebrafish Embryos.International journal of nanomedicine · 2020Article
- Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment.Cellular and molecular life sciences : CMLS · 2019Review
- Hybrid Nanoparticle Platform for Nanoscale Scintillation Proximity Assay.ACS applied nano materials · 2019Article
- Review
- Polystyrene-Core, Silica-Shell Scintillant Nanoparticles for Low-Energy Radionuclide Quantification in Aqueous Media.ACS applied materials & interfaces · 2018Article
- Facilitating Translational Nanomedicine via Predictive Safety Assessment.Molecular therapy : the journal of the American Society of Gene Therapy · 2017Review
- Co-exposure to amorphous silica nanoparticles and benzo[a]pyrene at low level in human bronchial epithelial BEAS-2B cells.Environmental science and pollution research international · 2016Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adverse effects of silica nanoparticles are gaining attention due to their wide application in biomedicine. However, information about size-dependent toxicity induced by silica nanoparticles is insufficient. In this study, two size of nano-scale (40 nm, 60 nm) and one size of micro-scale (200 nm) silica particles were studied to investigate the possible mechanism of cytotoxicity and autophagy dysfunction in human bronchial epithelial BEAS-2B cells. The cell viability was decreased in a size- and dose-dependent manner, while the LDH activity, oxidative stress and mitochondrial damage significantly increased, induced by both nano- and micro-scale silica particles. Ultrastructural analysis showed that nano-scale silica particles could induce mitochondrial damage and autophagy, but not micro-scale particles. Verified by the autophagy inhibitor 3-MA, the expression of LC3 and SQSTM1/p62 was upregulated in nano-scale silica particles in a size- and dose-dependent manner, while the micro-scale particles had an inhibitory effect. In addition, autophagy activation and autophagy blockage were triggered by nano-scale silica particles
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.