Evidence map›Paper›PMID 30090246›Full record

ArticleChemical science2015

Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage.

Weixin Tang, Shi-Hui Dong, Lindsay M Repka, Chang He, Satish K Nair, Wilfred A van der Donk

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. S9 protease WprPCommunications chemistry · 2026
    Article
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  4. Review
  5. Article
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  8. Review
  9. CylA is a sequence-specific protease involved in toxin biosynthesis.Journal of industrial microbiology & biotechnology · 2019
    Article
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  11. Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Weixin TangDepartment of Chemistry and Howard Hughes Medical Institute , University of Illinois at Urbana-Champaign , 600 S. Mathews Ave. , Urbana , IL 61801 , USA . Email: vddonk@illinois.edu ; ; Tel: +1 217 244 5360.
Shi-Hui DongDepartment of Biochemistry , University of Illinois at Urbana-Champaign , 600 S. Mathews Ave. , Urbana , IL 61801 , USA.
Lindsay M RepkaDepartment of Chemistry and Howard Hughes Medical Institute , University of Illinois at Urbana-Champaign , 600 S. Mathews Ave. , Urbana , IL 61801 , USA . Email: vddonk@illinois.edu ; ; Tel: +1 217 244 5360.
Chang HeDepartment of Chemistry and Howard Hughes Medical Institute , University of Illinois at Urbana-Champaign , 600 S. Mathews Ave. , Urbana , IL 61801 , USA . Email: vddonk@illinois.edu ; ; Tel: +1 217 244 5360.
Satish K NairDepartment of Biochemistry , University of Illinois at Urbana-Champaign , 600 S. Mathews Ave. , Urbana , IL 61801 , USA.
Wilfred A van der DonkDepartment of Chemistry and Howard Hughes Medical Institute , University of Illinois at Urbana-Champaign , 600 S. Mathews Ave. , Urbana , IL 61801 , USA . Email: vddonk@illinois.edu ; ; Tel: +1 217 244 5360.ORCID 0000-0002-5467-7071
Howard Hughes Medical Institute · USUniversity of Illinois Urbana-Champaign · US

Funding

Posttranslational Modifications in Natural Product BiosynthesisR01GM058822 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI VAN DER DONK, WILFRED A. · 1999 to 2015
$3.8M
Structural /Mechanistic Study of Lantibiotic Biosynthetic Enzymes & AutoimmunityR01GM079038 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI NAIR, SATISH K · 2006 to 2023
$3.7M
Posttranslational Modifications during Natural Product BiosynthesisR37GM058822 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI VAN DER DONK, WILFRED A. · 2016 to 2025
$2.9M
4800 Plus MALDI TOF/TOF AnalyzerS10RR027109 · NCRR · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI VAN DER DONK, WILFRED A. · 2010 to 2010
$395k
Mechanistic Understanding and Target Identification for Ribosomally Synthesized aF32GM108275 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI REPKA, LINDSAY MICHELLE · 2014 to 2015
$106k
NCRR NIH HHS S10 RR027109NIGMS NIH HHS F32 GM108275NIGMS NIH HHS R01 GM058822NIGMS NIH HHS R01 GM079038NIGMS NIH HHS R37 GM058822
6 · The paper itself

Abstract

The final step of lanthipeptide biosynthesis involves the removal of leader peptides by dedicated proteases.

Identifiers

PMID30090246
PMCPMC6054071
OpenAlexW1896209684

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.