Evidence map›Paper›PMID 30090183›Full record

ArticleJournal of ophthalmic & vision research

Analysis of VSX1 Variations in Brazilian Subjects with Keratoconus.

Dulceria Costa da Silva, Bianca Nery Benevides Gadelha, Alex Felipe Barbosa Feitosa, Rafaela Gomes da Silva, Tarsila Livia Paz E Albuquerque, Débora Christina Pereira Fernandes Santos, Diego Nery Benevides Gadelha, Bruno Luiz Fonseca Schamber-Reis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ophthalmic & vision research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Heritability of Corneal Parameters in Nuclear Families With Keratoconus.Translational vision science & technology · 2022
    Article
  3. Screening for NovelJournal of ophthalmic & vision research
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Dulceria Costa da SilvaDepartment of Medical Genetics, School of Medical Sciences, UNIFACISA, Campina Grande, Paraíba, Brazil.
Bianca Nery Benevides GadelhaDepartment of Medical Genetics, School of Medical Sciences, UNIFACISA, Campina Grande, Paraíba, Brazil.
Alex Felipe Barbosa FeitosaDepartment of Medical Genetics, School of Medical Sciences, UNIFACISA, Campina Grande, Paraíba, Brazil.
Rafaela Gomes da SilvaDepartment of Medical Genetics, School of Medical Sciences, UNIFACISA, Campina Grande, Paraíba, Brazil.
Tarsila Livia Paz E AlbuquerqueDepartment of Medical Genetics, School of Medical Sciences, UNIFACISA, Campina Grande, Paraíba, Brazil.
Débora Christina Pereira Fernandes SantosDepartment of Medical Genetics, School of Medical Sciences, UNIFACISA, Campina Grande, Paraíba, Brazil.
Diego Nery Benevides GadelhaDepartment of Medical Genetics, School of Medical Sciences, UNIFACISA, Campina Grande, Paraíba, Brazil.
Bruno Luiz Fonseca Schamber-ReisDepartment of Medical Genetics, School of Medical Sciences, UNIFACISA, Campina Grande, Paraíba, Brazil.
Universidade Estadual da Paraíba · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo screen visual system homeobox 1 (

methodsSeventy-three patients with KCN and 106 healthy controls were enrolled in this study. Patients were diagnosed with KCN based on eye examination and corneal topographic features according to Rabinowitz's criteria (K > 47.2, I-S > 1.4 and KISA > 100%). DNA from blood samples was extracted from donors, and the exons and exon-intron boundaries of

resultsWe found three non-synonymous substitutions (L68H, R131S, and D105E) in

conclusion

Indexed as

CorneaKeratoconusPolymorphismVSX1

Identifiers

PMID30090183
PMCPMC6058540
OpenAlexW2884433789

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.