ReviewFrontiers in physiology2018
Preeclampsia: Novel Mechanisms and Potential Therapeutic Approaches.
Review in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
98 citing papers in PubMed, 2 syntheses or guidelines pooled it, 195 citations in OpenAlex.
- Ultrasound evaluation of placental volume and placental vascular indices in women developing hypertensive disorders in pregnancy compared to controls: a systematic review and meta-analysis.European heart journal. Quality of care & clinical outcomes · 2026Pooled it
- Second trimester maternal serum D-dimer combined with alpha-fetoprotein and free β-subunit of human chorionic gonadotropin predict hypertensive disorders of pregnancy: a systematic review and retrospective case-control study.Journal of translational medicine · 2021Pooled it
- Long non-coding RNA maternally expressed gene 3 (Turkish journal of obstetrics and gynecology · 2026Article
- Endothelial Dysfunction in Preeclampsia: Focus on the Uteroplacental Circulation.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Investigating the impact of hypoxia and syncytialization on lipid nanoparticle-mediated mRNA delivery to placental cells.Bioengineering & translational medicine · 2026Article
- Review
- Article
- Inflammatory and fibrosis indices (UA/Alb, Fib/UA, UA/Cr, Cr/BW, AST/PLT, AST/ALT, FIB-4, and FIB-5) as predictors of preeclampsia-associated systemic dysfunction.BMC pregnancy and childbirth · 2025Article
- Long-term microvascular and blood pressure dysregulation after Preeclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- The incidence and influencing factors of hypertensive disorders during pregnancy in hangzhou, China, between 2012 and 2021.Heliyon · 2025Article
- A Review of Dietary and Lifestyle Management of Pre-Eclampsia and Postpartum Eclampsia.Preventive nutrition and food science · 2025Review
- Correlation of uric acid and lipid levels with preeclampsia and final pregnancy outcome in late pregnancy.American journal of translational research · 2025Article
- Exploring the ceRNA network involving AGAP2-AS1 as a novel biomarker for preeclampsia.Scientific reports · 2024Article
- Understanding the role of soluble proteins and exosomes in non-invasive urine-based diagnosis of preeclampsia.Scientific reports · 2024Article
- The Hidden Relationship between Intestinal Microbiota and Immunological Modifications in Preeclampsia Pathogenesis.International journal of molecular sciences · 2024Review
- Alpha 1,3 N-Acetylgalactosaminyl Transferase (GTA) Impairs Invasion Potential of Trophoblast Cells in Preeclampsia.International journal of molecular sciences · 2024Article
- IL-33 Signaling Inhibition Leads to a Preeclampsia-Like Phenotype in Pregnant Rats.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024Article
- Systematic development of ionizable lipid nanoparticles for placental mRNA delivery using a design of experiments approach.Bioactive materials · 2024Article
- IL-33 supplementation improves uterine artery resistance and maternal hypertension in response to placental ischemia.American journal of physiology. Heart and circulatory physiology · 2024Article
- Evaluating mean platelet volume and platelet distribution width as predictors of early-onset pre-eclampsia: a prospective cohort study.Maternal health, neonatology and perinatology · 2024Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preeclampsia is a serious complication of pregnancy where it affects 5-8% of all pregnancies. It increases the morbidity and mortality of both the fetus and pregnant woman, especially in developing countries. It deleteriously affects several vital organs, including the kidneys, liver, brain, and lung. Although, the pathogenesis of preeclampsia has not yet been fully understood, growing evidence suggests that aberrations in the angiogenic factors levels and coagulopathy are responsible for the clinical manifestations of the disease. The common nominator of tissue damage of all these target organs is endothelial injury, which impedes their normal function. At the renal level, glomerular endothelial injury leads to the development of maternal proteinuria. Actually, peripheral vasoconstriction secondary to maternal systemic inflammation and endothelial cell activation is sufficient for the development of preeclampsia-induced hypertension. Similarly, preeclampsia can cause hepatic and neurologic dysfunction due to vascular damage and/or hypertension. Obviously, preeclampsia adversely affects various organs, however it is not yet clear whether pre-eclampsia
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.