ArticleIntestinal research2018
Immunohistochemical differentiation between chronic enteropathy associated with
Article in Intestinal research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- What we know about prostaglandin pathway dysfunction in chronic enteropathies: From endoscopy to molecular diagnosis.Journal of translational internal medicine · 2026Article
- Is There a Reliable, Rapid, and Economic Diagnostic Approach for SLCO2A1-Related Chronic Enteropathy?Journal of clinical medicine · 2026Article
- BiallelicFrontiers in endocrinology · 2026Article
- Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children.The American journal of clinical nutrition · 2024Article
- Characteristics of chronic enteropathy associated with SLCO2A1 gene (CEAS) in children, a unique type of monogenic very early-onset inflammatory bowel disease.BMC pediatrics · 2024Article
- Clinical and genetic characteristics of Chinese patients diagnosed with chronic enteropathy associated with SLCO2A1 gene.Orphanet journal of rare diseases · 2024Article
- First case report of dichorionic diamniotic twins with chronic enteropathy associated with the SLCO2A1 gene.Clinical journal of gastroenterology · 2024Article
- Clinical and Genetic Characteristics of Korean Patients Diagnosed with Chronic Enteropathy Associated withGut and liver · 2022Article
- Chronic Enteropathy Associated with Solute Carrier Organic Anion Transporter Family, Member 2A1 (SLCO2A1) with Positive Immunohistochemistry for SLCO2A1 Protein.Internal medicine (Tokyo, Japan) · 2022Article
- Epithelial Abnormalities in the Small Intestine of Zambian Children With Stunting.Frontiers in medicine · 2022Article
- Meta-Analysis-Assisted Detection of Gravity-Sensitive Genes in Human Vascular Endothelial Cells.Frontiers in cell and developmental biology · 2021Article
- Retrospective study of the differential diagnosis between cryptogenic multifocal ulcerous stenosing enteritis and small bowel Crohn's disease.BMC gastroenterology · 2020Article
- Chronic Enteropathy Associated with SLCO2A1 with Pachydermoperiostosis.Internal medicine (Tokyo, Japan) · 2020Article
- Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations.World journal of gastroenterology · 2019Observational
- Distinction between Chronic Enteropathy Associated with theGut and liver · 2019Article
- Chronic Enteropathy Associated withInflammatory intestinal diseasesReview
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsWe recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (
methodsImmunohistochemical staining using a polyclonal anti-SLCO2A1 antibody was performed on the resected intestinal specimens from 13 cases of CD, 9 cases of intestinal BD/SU, and 3 cases of CEAS. The extent of SLCO2A1 expression was determined by counting positively-staining vascular endothelial cells and scored as 0 (no cells), 1 (1%-30% cells), 2 (31%-60%), or 3 (>60%). The intensity of SLCO2A1 expression was scored either as 0 (negative), 1 (intermediate), or 2 (strong). The extent score and intensity score were summed for the final score of 0, 2, 3, 4, or 5.
resultsSLCO2A1 protein expression was observed in 1 of 3 cases of CEAS (33%), all 13 cases of CD (100%), and all 9 cases of BD/SU (100%). The mean final expression scores of CEAS, CD, and BD/SU were 1.6 (range, 0-5), 4.8 (range, 4-5), and 4.3 (range, 4-5), respectively. The final expression score in CEAS was significantly lower than in CD (
conclusionsImmunohistochemical staining of the SLCO2A1 protein is considered useful to distinguish CEAS from other inflammatory bowel diseases.
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