ReviewIntestinal research2018
Serrated neoplasia pathway as an alternative route of colorectal cancer carcinogenesis.
Review in Intestinal research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- The 'other' colonic polyposis syndromes-evolving insights and guidance for endoscopists.International journal of colorectal disease · 2026Review
- Distinguishing colorectal sessile serrated lesions from hyperplastic polyps: development of a prediction model based on logistic regression.BMC gastroenterology · 2026Article
- Genetic and Epigenetic Mechanisms in Serrated Adenocarcinomas and Classical Colorectal Carcinomas: An In Silico Study.Current issues in molecular biology · 2026Article
- Stool-based SDC2/SFRP2/TFPI2 methylation assay for colorectal neoplasia screening: a multicenter, case-control study.Frontiers in oncology · 2026Article
- Mixed lesions in premalignant colorectal polyps.Journal of clinical biochemistry and nutrition · 2026Article
- Construction and validation of a risk nomogram model for colorectal sessile serrated lesions.The Journal of international medical research · 2025Article
- Serum DNA methylome of the colorectal cancer serrated pathway enables non-invasive detection.Molecular oncology · 2024Article
- Different modifiable risk factors for the development of non-advanced adenoma, advanced adenomatous lesion, and sessile serrated lesions, on screening colonoscopy.Scientific reports · 2024Article
- Summary and comparison of recently updated post-polypectomy surveillance guidelines.Intestinal research · 2023Review
- Escape from oncogene-induced senescence is controlled by POU2F2 and memorized by chromatin scars.Cell genomics · 2023Article
- Sessile serrated lesion detection rates continue to increase: 2008-2020.Endoscopy international open · 2023Article
- Left-sided colorectal cancer distinct in indigenous African patients compared to other ethnic groups in South Africa.BMC cancer · 2022Article
- Diabetes mellitus in relation to colorectal tumor molecular subtypes: A pooled analysis of more than 9000 cases.International journal of cancer · 2022Article
- EGFR and BRAF mutations in inverted sinonasal papilloma - a more complex landscape?Virchows Archiv : an international journal of pathology · 2021Article
- Postgastrectomy gastric cancer patients are at high risk for colorectal neoplasia: a case control study.Intestinal research · 2021Article
- Multitarget Stool DNA Test Performance in an Average-Risk Colorectal Cancer Screening Population.The American journal of gastroenterology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the past two decades, besides conventional adenoma pathway, a subset of colonic lesions, including hyperplastic polyps, sessile serrated adenoma/polyps, and traditional serrated adenomas have been suggested as precancerous lesions via the alternative serrated neoplasia pathway. Major molecular alterations of sessile serrated neoplasia include BRAF mutation, high CpG island methylator phenotype, and escape of cellular senescence and progression via methylation of tumor suppressor genes or mismatch repair genes. With increasing information of the morphologic and molecular features of serrated lesions, one major challenge is how to reflect this knowledge in clinical practice, such as pathologic and endoscopic diagnosis, and guidelines for treatment and surveillance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.