ArticleClinical medicine insights. Ear, nose and throat2018
Characteristics of Sinus Fungus Ball: A Unique Form of Rhinosinusitis.
Article in Clinical medicine insights. Ear, nose and throat, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- A Case of Allergic Fungal Sinusitis-Like Syndrome: Clinical and Immunopathological Comparison With Allergic Bronchopulmonary Aspergillosis.Journal of rhinology : official journal of the Korean Rhinologic Society · 2026Article
- Non-viableMicrobiology spectrum · 2026Article
- Nasal cavity fungus ball discovered accidentally: A case report.World journal of clinical cases · 2025Article
- Unprecedented Finding of Isolated Sphenoid Fungal Ball in a Child: A Case Report.Case reports in otolaryngology · 2025Article
- The accuracy of deep learning models for diagnosing maxillary fungal ball rhinosinusitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Periantral fungal abscess after zygoma reduction: a case report.Archives of craniofacial surgery · 2023Article
- A study on the fungal rhinosinusitis: Causative agents, symptoms, and predisposing factors.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Article
- The Endonasal Endoscopic Approach to Different Sinonasal Fungal Balls.International journal of otolaryngology · 2022Article
- High CT Attenuation Values Relative to the Brainstem Predict Fungal Hyphae Within the Sinus.Frontiers in surgery · 2022Article
- The immune response to airway mycosis.Current opinion in microbiology · 2021Review
- Article
- Phenotypes in Chronic Rhinosinusitis.Current allergy and asthma reports · 2020Review
- Clinical Characteristics Other Than Intralesional Hyperdensity May Increase the Preoperative Diagnostic Accuracy of Maxillary Sinus Fungal Ball.Clinical and experimental otorhinolaryngology · 2020Article
- MR Findings of Fungus Ball: Significance of High Signal Intensity on T1-Weighted Images.Journal of Korean medical science · 2020Article
- Histoplasma capsulatum causing sinusitis: a case report in French Guiana and review of the literature.BMC infectious diseases · 2018Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this study was to investigate the characteristics of this unique form of rhinosinusitis.
methodsNinety-one patients with sinus fungus balls were evaluated for clinical characteristics. Nasal tissues obtained from 38 patients with sinus fungus ball, along with 26 controls were used for histopathological, cytokines/chemokines, western blotting, and genetic analyses.
resultsPatients with fungus balls had significantly more females and their age was older. The presentation of fungus ball was predominantly unilateral (97.8%). Thirty-three patients (36.3%) had risk factors for fungal infection. Macrophage and neutrophil dominated cellular infiltration was found in nasal tissues of fungus ball patients. A tendency of reduced tight junction staining (e-cadherin) and protein expression was found. Interleukin 8 (IL8) and granulocyte colony stimulating factor (G-CSF) significantly increased in sinus fungus ball tissue homogenates when compared with those from controls. Higher prevalence of a single single nucleotide polymorphism (SNP) with E-cadherin was found in the patients with fungus ball.
conclusionsWe found that patients with sinus fungus ball had robust immune responses, allowing recruitment and activation of macrophages and neutrophils. However, patients with sinus fungus ball could have genetic or acquired weakness in immunity. The fungal hyphae were localized and accumulated within single sinus instead of being eradicated by host.
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