Evidence map›Paper›PMID 30089900›Full record

Trial reportBone marrow transplantation2019

Impact of the 2014 NIH chronic graft-versus-host disease scoring criteria modifications assessed in a large cohort of severely affected patients.

Ana Zelic Kerep, Jacob Broome, Filip Pirsl, Lauren M Curtis, Seth M Steinberg, Sandra A Mitchell, Edward W Cowen, Dominique C Pichard, Galen O Joe, Leora E Comis and 14 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Bone marrow transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Organ Changes Associated with Provider-Assessed Responses in Patients with Chronic Graft-versus-Host Disease.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019
    Observational
  9. Article
  10. Challenges in Conducting Studies in Chronic Graft-Clinical hematology international · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Ana Zelic KerepExperimental Transplantation and Immunology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA. ana.zelickerep@nih.gov.
Jacob BroomeExperimental Transplantation and Immunology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Filip PirslExperimental Transplantation and Immunology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-7919-0211
Lauren M CurtisExperimental Transplantation and Immunology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Seth M SteinbergBiostatistics and Data Management Section, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA.
Sandra A MitchellOutcomes Research Branch, Division of Cancer Control and Population Sciences, CCR, NCI, NIH, Rockville, MD, USA.
Edward W CowenDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, USA.
Dominique C PichardDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, USA.
Galen O JoeRehabilitation Medicine Department, Clinical Center, NIH, Bethesda, MD, USA.
Leora E ComisRehabilitation Medicine Department, Clinical Center, NIH, Bethesda, MD, USA.
Jacqueline W MaysNational Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA.
Manuel B DatilesNational Eye Institute, NIH, Bethesda, MD, USA.
Pamela StrattonEunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
Jessica ZoltonEunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
Ann BergerDepartment of Pain and Palliative Care, Clinical Center, NIH, Bethesda, MD, USA.
Jennifer HendricksSocial Work Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Megan KenyonExperimental Transplantation and Immunology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Judy BaruffaldiExperimental Transplantation and Immunology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Irina TitarenkoOffice of the Clinical Director, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA.
Drazen PulanicDivision of Hematology, Department of Internal Medicine, University Hospital Center Zagreb, Zagreb, Croatia.
Kristin BairdPediatric Oncology Branch, CCR, NCI, NIH, Bethesda, MD, USA.
Daniel H FowlerExperimental Transplantation and Immunology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Ronald E GressExperimental Transplantation and Immunology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Steven Z PavleticExperimental Transplantation and Immunology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.

Funding

Immunobiology and therapy of oral mucosal and salivary gland chronic graft-versus-host diseaseZIADE000747 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI MAYS, JACQUELINE · 2016 to 2025
$14.9M
NIH Chronic GVHD Study GroupZIABC011743 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PAVLETIC, STEVEN · 2016 to 2025
$10.2M
Intramural NIH HHS ZIA BC011743
6 · The paper itself

Abstract

In 2005, the National Institutes of Health (NIH) chronic graft-versus-host disease (cGVHD) consensus project provided diagnosis and staging criteria, based mostly on clinical experience and expert opinion. These criteria were revised in 2014, aiming to provide enhanced specificity and clarity. However, the impact of 2014 changes to the original NIH cGVHD severity scoring criteria has not been reported. In this study, 284 patients, prospectively enrolled on the National Cancer Institute's cross-sectional cGVHD natural history study, were scored using the 2005 NIH cGVHD criteria and then rescored according to the 2014 modifications. In comparing the two criteria, 2014 cGVHD global severity scoring resulted in a tendency toward being categorized as milder scores (75 vs. 72% of severe score per 2014, p = 0.0009), with a statistically significant shift in NIH liver and lung scores toward milder categories (p < 0.0001). 2005 and 2014 NIH global severity scores showed a significant association with reduced grip strength (p < 0.0001), reduced joint range of motion (p = 0.0003), and the subspecialist evaluation score (p < 0.0001). Poor survival prediction of the severe NIH lung score is also retained in the new criteria (p = 0.0012). These findings support the use of 2014 cGVHD scoring criteria in continuous efforts to develop better classification systems.

Indexed as

Graft vs Host DiseaseLiver DiseasesSeverity of Illness IndexAdultAgedChronic DiseaseCross-Sectional StudiesFemaleHumansLung DiseasesMaleMiddle AgedNational Cancer Institute (U.S.)United States

Identifiers

PMID30089900
PMCPMC8268758

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.