Evidence map›Paper›PMID 30089795›Full record

ArticleNature communications2018

γδ T cells control humoral immune response by inducing T follicular helper cell differentiation.

Rafael M Rezende, Amanda J Lanser, Stephen Rubino, Chantal Kuhn, Nathaniel Skillin, Thais G Moreira, Shirong Liu, Galina Gabriely, Bruna A David, Gustavo B Menezes and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Article
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  8. Review
  9. Article
  10. Article
  11. γδ T Cells' Role in Donor-Specific Antibody Generation: Insights From Transplant Recipients and Experimental Models.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Article
  12. Article
  13. Review
  14. γδ T cells in immune-mediated kidney disease.European journal of immunology · 2024
    Review
  15. Article
  16. Intestinal CXCR6Immunity · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Rafael M RezendeAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. rmachadorezende@bwh.harvard.edu.
Amanda J LanserAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Stephen RubinoAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Chantal KuhnAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Nathaniel SkillinAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Thais G MoreiraAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Shirong LiuAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Galina GabrielyAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Bruna A DavidCenter for Gastrointestinal Biology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Gustavo B MenezesCenter for Gastrointestinal Biology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Howard L WeinerAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Brigham and Women's Hospital · USHarvard University · USUniversidade Federal de Minas Gerais · BR

Funding

MECHANISMS OF THE INDUCTION OF ORAL TOLERANCER01AI043458 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI WEINER, HOWARD L · 1998 to 2015
$5.0M
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01 AI43458NIAID NIH HHS R01 AI043458
6 · The paper itself

Abstract

γδ T cells have many known functions, including the regulation of antibody responses. However, how γδ T cells control humoral immunity remains elusive. Here we show that complete Freund's adjuvant (CFA), but not alum, immunization induces a subpopulation of CXCR5-expressing γδ T cells in the draining lymph nodes. TCRγδ

Indexed as

Cell DifferentiationAlum CompoundsAnimalsAntibody FormationAutoantibodiesChickensFemaleFreund's AdjuvantGlomerulonephritisImmunity, HumoralImmunizationIntraepithelial LymphocytesKidney GlomerulusLymph NodesLymphocyte ActivationMaleAlum Compoundsaluminum sulfateAutoantibodiesFreund's AdjuvantOvalbuminReceptors, CXCR5

Identifiers

PMID30089795
PMCPMC6082880
OpenAlexW2887767463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.