Evidence map›Paper›PMID 30089703›Full record

ArticleJournal of virology2018

Epstein-Barr Virus Type 2 Infects T Cells and Induces B Cell Lymphomagenesis in Humanized Mice.

Carrie B Coleman, Julie Lang, Lydia A Sweet, Nicholas A Smith, Brian M Freed, Zenggang Pan, Bradley Haverkos, Roberta Pelanda, Rosemary Rochford

Abstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. EBV Genome Variations and Association With Diseases.Journal of medical virology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carrie B Coleman *Department of Immunology and Microbiology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Julie Lang *Department of Immunology and Microbiology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Lydia A SweetDepartment of Immunology and Microbiology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Nicholas A SmithDepartment of Immunology and Microbiology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Brian M FreedDivision of Allergy and Clinical Immunology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Zenggang PanDepartment of Pathology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Bradley HaverkosDepartment of Hematology and Oncology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado USA.
Roberta PelandaDepartment of Immunology and Microbiology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Rosemary RochfordDepartment of Immunology and Microbiology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA rosemary.rochford@ucdenver.edu.

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Studies of human B cell tolerance, from a humanized mouse model to human beingsR01AI124474 · NIAID · UNIVERSITY OF COLORADO DENVER · PI PELANDA, ROBERTA · 2016 to 2020
$2.3M
Human B Cell Development and Function in Humanized Mice Expressing Human BAFFR21AI105523 · NIAID · UNIVERSITY OF COLORADO DENVER · PI PELANDA, ROBERTA · 2013 to 2014
$433k
Developing a new model for EBV-mediated T cell diseasesR21AI122670 · NIAID · UNIVERSITY OF COLORADO DENVER · PI PELANDA, ROBERTA, ROCHFORD, ROSEMARY · 2016 to 2017
$428k
NCI NIH HHS L30 CA189070NCI NIH HHS P30 CA046934NIAID NIH HHS R01 AI124474NIAID NIH HHS R21 AI105523NIAID NIH HHS R21 AI122670
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) has been classified into two strains, EBV type 1 (EBV-1) and EBV type 2 (EBV-2) based on genetic variances and differences in transforming capacity. EBV-1 readily transforms B cells in culture while EBV-2 is poorly transforming. The differing abilities to immortalize B cells

Indexed as

AnimalsB-LymphocytesCarcinogenesisDisease Models, AnimalEpstein-Barr Virus InfectionsHerpesvirus 4, HumanHumansLymphoma, Large B-Cell, DiffuseMiceMice, Inbred BALB CMice, KnockoutT-LymphocytesViral TropismVirus ActivationVirus LatencyB cell lymphomaB lymphocytesEpstein-Barr virushumanized mouse modelT lymphocytes

Identifiers

PMID30089703
PMCPMC6189503

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.