Evidence map›Paper›PMID 30089695›Full record

ArticleJournal of virology2018

Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.

Michael A Rak, Jason Buehler, Sebastian Zeltzer, Justin Reitsma, Belen Molina, Scott Terhune, Felicia Goodrum

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Review
  3. Viral and host network analysis of the human cytomegalovirus transcriptome in latency.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Adaptor protein Abelson interactor 1 in homeostasis and disease.Cell communication and signaling : CCS · 2024
    Review
  6. Article
  7. Human cytomegalovirus and neonatal infection.Current research in microbial sciences · 2024
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Mouse Models for Human Herpesviruses.Pathogens (Basel, Switzerland) · 2023
    Review
  13. Article
  14. Article
  15. Hematopoietic stem cells and betaherpesvirus latency.Frontiers in cellular and infection microbiology · 2023
    Review
  16. Article
  17. Review
  18. Article
  19. Evasion of the Host Immune Response by Betaherpesviruses.International journal of molecular sciences · 2021
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Michael A RakDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, USA.
Jason BuehlerBIO5 Institute, University of Arizona, Tucson, Arizona, USA.
Sebastian ZeltzerDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, USA.
Justin ReitsmaDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Belen MolinaDepartment of Immunobiology, University of Arizona, Tucson, Arizona, USA.
Scott TerhuneDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Felicia GoodrumDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, USA fgoodrum@email.arizona.edu.
University of Arizona · USMedical College of Wisconsin · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2M
The Administrative CoreP01AI127335 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI JAY A NELSON · 2017 to 2026
$24.6M
Mechanisms of Human Cytomegalovirus Latency in Primary Human Hematopoietic CellsR01AI079059 · NIAID · UNIVERSITY OF ARIZONA · PI GOODRUM, FELICIA D · 2008 to 2018
$4.4M
Mechanisms of Human Cytomegalovirus Latency in Primary Human Hematopoietic CellsR37AI079059 · NIAID · UNIVERSITY OF ARIZONA · PI Felicia D Goodrum · 2019 to 2026
$3.3M
Impact of HCMV proteins on viral replication and cellular signaling pathwaysR01AI083281 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI TERHUNE, SCOTT SLETTEN · 2011 to 2020
$3.2M
CMV Control of Host Membrane TraffickingR01AI131598 · NIAID · UNIVERSITY OF ARIZONA · PI GOODRUM, FELICIA D, WILSON, JEAN M · 2018 to 2022
$2.1M
NCI NIH HHS P30 CA023074NIAID NIH HHS P01 AI127335NIAID NIH HHS R01 AI079059NIAID NIH HHS R01 AI083281NIAID NIH HHS R01 AI131598NIAID NIH HHS R37 AI079059
6 · The paper itself

Abstract

Human cytomegalovirus, HCMV, is a betaherpesvirus that establishes a lifelong latent infection in its host that is marked by recurrent episodes of reactivation. The molecular mechanisms by which the virus and host regulate entry into and exit from latency remain poorly understood. We have previously reported that

Indexed as

Host-Pathogen InteractionsVirus ActivationAdaptor Proteins, Signal TransducingAmino Acid SubstitutionAnimalsCells, CulturedCytomegalovirusCytoskeletal ProteinsDNA Mutational AnalysisErbB ReceptorsGene Expression RegulationHumansMutant ProteinsProtein Interaction MappingReverse GeneticsViral ProteinsABI1 protein, humanAdaptor Proteins, Signal TransducingCytoskeletal ProteinsErbB ReceptorsMutant ProteinsSH3KBP1 protein, humanUL135 protein, human herpesvirus 5Viral ProteinscytomegalovirusEGFRhuman herpesviruseslatencyRab5UL135

Identifiers

PMID30089695
PMCPMC6158428
OpenAlexW2885528297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.