Observational studyPediatrics2018
Neuroimaging of Early Life Epilepsy.
Observational study in Pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Guideline
- When Should a Brain MRI Be Performed in Children with New-Onset Seizures? Results of a Large Prospective Trial.AJNR. American journal of neuroradiology · 2021Trial
- Age-specific MRI patterns in pediatric epilepsy: insights from a sudanese cohort and implications for low-resources settings.BMC medical imaging · 2026Article
- The diagnostic value of semiology, EEG and MRI in new-onset pediatric bilateral tonic-clonic seizures: A multimodal analysis.Epilepsia open · 2026Article
- Factors Influencing the Response of Patients with Infantile Epileptic Spasms Syndrome to ACTH as Repeated First-Line Therapy.Neurology and therapy · 2025Article
- Synergy in Child Neurology: Science, Collaboration, and Leadership - The 2024 Hower Award Lecture.Annals of the Child Neurology Society · 2025Article
- Predictive model for initial response to first-line treatment in children with infantile epileptic spasms syndrome.Italian journal of pediatrics · 2025Article
- Clinical, Genetic, EEG, Neuroimaging Insights and Conservative Treatment in Pediatric Focal Epilepsy: A Retrospective Observational Study.Journal of clinical medicine · 2025Article
- Prenatal assessment of brain malformations on neuroimaging: an expert panel review.Brain : a journal of neurology · 2024Review
- Optimal lead time for treatment of infantile epileptic spasms syndrome-a secondary data analysis.Translational pediatrics · 2024Article
- Exhaustive clinical examination of etiology and initial response to first-line treatment in 577 children with infantile epileptic spasm syndrome children: A 5-year retrospective observational study.Annals of clinical and translational neurology · 2024Observational
- Genetic Epilepsies and Developmental Epileptic Encephalopathies with Early Onset: A Multicenter Study.International journal of molecular sciences · 2024Article
- Effectiveness and safety analysis of ketogenic diet therapy for drug-resistant epilepsy caused by structural pathology.Frontiers in neurology · 2024Article
- Prevalence and Risk Factors for Pharmacoresistance in Children With Focal Cortical Dysplasia-Related Epilepsy.Neurology · 2022Article
- Narrative review of epilepsy: getting the most out of your neuroimaging.Translational pediatrics · 2021Review
- Article
- International consensus recommendations on the diagnostic work-up for malformations of cortical development.Nature reviews. Neurology · 2020Review
- Infants routine video electroencephalogram findings in a Saudi tertiary hospital.Neurosciences (Riyadh, Saudi Arabia) · 2020Article
- Neuroimaging in Pediatric Epilepsy.Brain sciences · 2019Article
- Immediate outcomes in early life epilepsy: A contemporary account.Epilepsy & behavior : E&B · 2019Article
Corrections and comments
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Authors and funding
16 authors at 15 institutions in 1 country.
Funding
Abstract
objectivesWe assessed the adherence to neuroimaging guidelines and the diagnostically relevant yield of neuroimaging in newly presenting early life epilepsy (ELE).
methodsThere were 775 children with a new diagnosis of epilepsy (<3 years old at onset) who were recruited through the ELE study at 17 US pediatric epilepsy centers (2012-2015) and managed prospectively for 1 year. The data were analyzed to assess the proportion of children who underwent neuroimaging, the type of neuroimaging, and abnormalities.
resultsOf 725 children (93.5%) with neuroimaging, 714 had an MRI (87% with seizure protocols) and 11 had computed tomography or ultrasound only. Etiologically relevant abnormalities were present in 290 individuals (40%) and included: an acquired injury in 97 (13.4%), malformations of cortical development in 56 (7.7%), and other diffuse disorders of brain development in 51 (7.0%). Neuroimaging was abnormal in 160 of 262 (61%) children with abnormal development at diagnosis versus 113 of 463 (24%) children with typical development. Neuroimaging abnormalities were most common in association with focal seizure semiology (40%), spasms (47%), or unclear semiology (42%). In children without spasms or focal semiology with typical development, 29 of 185 (16%) had imaging abnormalities. Pathogenic genetic variants were identified in 53 of 121 (44%) children with abnormal neuroimaging in whom genetic testing was performed.
conclusionsStructural abnormalities occur commonly in ELE, and adherence to neuroimaging guidelines is high at US pediatric epilepsy centers. These data support the universal adoption of imaging guidelines because the yield is substantially high, even in the lowest risk group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.