Evidence map›Paper›PMID 30089641›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Persistent Spiking Activity Underlies Working Memory.

Christos Constantinidis, Shintaro Funahashi, Daeyeol Lee, John D Murray, Xue-Lian Qi, Min Wang, Amy F T Arnsten

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed.

  1. Trial
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  14. Review
  15. Article
  16. Asynchronous firing and off-states in working memory maintenance.bioRxiv : the preprint server for biology · 2025
    Article
  17. Article
  18. Robustness of Working Memory to Prefrontal Cortex Microstimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  19. Article
  20. Article

102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christos ConstantinidisDepartment of Neurobiology & Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, cconstan@wakehealth.edu.
Shintaro FunahashiKokoro Research Center, Kyoto University, Yoshida Sakyo-ku, Kyoto, 606-8501, Japan.
Daeyeol LeeDepartment of Neuroscience, Yale School of Medicine, New Haven, Connecticut 06510.ORCID 0000-0003-3474-019X
John D MurrayDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06511.ORCID 0000-0003-4115-8181
Xue-Lian QiDepartment of Neurobiology & Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157.
Min WangDepartment of Neuroscience, Yale School of Medicine, New Haven, Connecticut 06510.ORCID 0000-0001-6112-2608
Amy F T ArnstenDepartment of Neuroscience, Yale School of Medicine, New Haven, Connecticut 06510.

Funding

NEUROPHYSIOLOGICAL EFFECTS OF TRAINING IN VISUAL COGNITIVE TASKSR01EY017077 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CHRISTOS CONSTANTINIDIS · 2006 to 2026
$6.0M
Highly evolved brain circuits in primates: molecular vulnerabilities for diseaseDP1AG047744 · NIA · YALE UNIVERSITY · PI ARNSTEN, AMY F.T. · 2013 to 2017
$4.1M
Rapid actions of ketamine in the prefrontal cortexR01MH108643 · NIMH · YALE UNIVERSITY · PI ARNSTEN, AMY F.T. · 2016 to 2020
$3.3M
CORTICAL CIRCUIT BASIS OF VISUAL SPATIAL PROCESSINGR01EY016773 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CONSTANTINIDIS, CHRISTOS · 2008 to 2017
$2.3M
Neural Basis of temporal decision makingR01MH108629 · NIMH · YALE UNIVERSITY · PI LEE, DAEYEOL · 2016 to 2020
$2.2M
Decision Making and Orbitofrontal CortexR01DA029330 · NIDA · YALE UNIVERSITY · PI LEE, DAEYEOL · 2010 to 2015
$2.0M
Linking Large-Scale Dysconnectivity in Schizophrenia to Cortical Circuit Function at the Individual Level through Computational Modeling and Multimodal NeuroimagingR01MH112746 · NIMH · YALE UNIVERSITY · PI MURRAY, JOHN DAVID · 2017 to 2020
$1.7M
NEI NIH HHS R01 EY016773NEI NIH HHS R01 EY017077NIA NIH HHS DP1 AG047744NIDA NIH HHS R01 DA029330NIMH NIH HHS R01 MH108629NIMH NIH HHS R01 MH108643NIMH NIH HHS R01 MH112746
6 · The paper itself

Abstract

Persistent activity generated in the PFC during the delay period of working memory tasks represents information about stimuli held in memory and determines working memory performance. Alternative models of working memory, depending on the rhythmicity of discharges or exclusively on short-term synaptic plasticity, are inconsistent with the neurophysiological data.

Indexed as

Models, NeurologicalAction PotentialsAnimalsArtifactsElectrodes, ImplantedFixation, OcularHaplorhiniHumansMemory, Short-TermNerve NetNeural Networks, ComputerNeuronsPrefrontal CortexResearch DesignSaccadesSynapsesdelay periodmonkeyneurophysiologyprefrontal cortexworking memory

Identifiers

PMID30089641
PMCPMC6083457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.