ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2018
Extracellular volume fraction measurements derived from the longitudinal relaxation of blood-based synthetic hematocrit may lead to clinical errors in 3 T cardiovascular magnetic resonance.
Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Society for Cardiovascular Magnetic Resonance reference values ("normal values") in cardiovascular magnetic resonance: 2025 update.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025Guideline
- Guidelines for Cardiovascular Magnetic Resonance Imaging from the Korean Society of Cardiovascular Imaging-Part 3: Perfusion, Delayed Enhancement, and T1- and T2 Mapping.Korean journal of radiology · 2019Guideline
- Synthetic Extracellular Volume in Cardiac Magnetic Resonance Without Blood Sampling: a Reliable Tool to Replace Conventional Extracellular Volume.Circulation. Cardiovascular imaging · 2022Trial
- Excellent Reproducibility of Synthetic Extracellular Volume Without Blood Extraction Across Different Cardiomyopathies Using Published Regression Models.Journal of cardiovascular development and disease · 2026Article
- Demographically informed models for improving synthetic haematocrit and extracellular volume estimation in cardiac computed tomography.European heart journal. Imaging methods and practice · 2026Article
- Optimizing synthetic hematocrit for cardiac MRI: a multivariable model calibrated with standardized venous sampling.The international journal of cardiovascular imaging · 2025Article
- Scanner-generated native T1 mapping: a novel approach for assessing myocardial fibrosis in coronary heart disease.Frontiers in cardiovascular medicine · 2025Article
- Deep Learning Virtual Contrast-Enhanced T1 Mapping for Contrast-Free Myocardial Extracellular Volume Assessment.Journal of the American Heart Association · 2024Article
- Importance of T1-Mapping Sequence in Patients with Hypertrophic Cardiomyopathy without Foci of Non-Ischemic Myocardial Injury in Late Gadolinium Enhancement Sequence.Biomedicines · 2024Article
- A comparative study of synthetic and venous hematocrit for calculating cardiovascular magnetic resonance-derived extracellular volume.The international journal of cardiovascular imaging · 2024Article
- Quantification of myocardial extracellular volume without blood sampling.European heart journal. Imaging methods and practice · 2023Article
- Cardiac MRI-derived Extracellular Volume Fraction versus Myocardium-to-Lumen R1 Ratio at Postcontrast T1 Mapping for Detecting Cardiac Amyloidosis.Radiology. Cardiothoracic imaging · 2023Article
- Myocardial extracellular volume fraction quantification in an animal model of the doxorubicin-induced myocardial fibrosis: a synthetic hematocrit method using 3T cardiac magnetic resonance.Quantitative imaging in medicine and surgery · 2021Article
- Reference ranges ("normal values") for cardiovascular magnetic resonance (CMR) in adults and children: 2020 update.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Review
- Is a timely assessment of the hematocrit necessary for cardiovascular magnetic resonance-derived extracellular volume measurements?Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Article
- Journal of Cardiovascular Magnetic Resonance: 2017/2018 in review.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019Review
- Myocardial T1 and ECV Measurement: Underlying Concepts and Technical Considerations.JACC. Cardiovascular imaging · 2019Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe extracellular volume (ECV), derived from cardiovascular magnetic resonance (CMR) T1 mapping, is a biomarker of the extracellular space in the myocardium. The hematocrit (HCT), measured from venipuncture, is required for ECV measurement. We test the clinic values of synthetic ECV, which is derived from the longitudinal relaxation of blood-based (T1
methodsA total of 226 subjects with CMR T1 mapping and HCT measurement taken on the same day as the CMR were retrospectively enrolled and randomly split into derivation (n = 121) and validation (n = 105) groups, comprising healthy subjects (n = 45), type 2 diabetes mellitus (T2DM) patients (n = 60), hypertrophic cardiomyopathy (HCM) patients (n = 93), and 28 other patients. Correlation of T1
resultsRegression between the HCTm and 1/T1
conclusionsECVsyn derived from HCTsyn may lead to clinical errors in 3 T CMR, especially for patients who have only a subtle elevation in ECV.
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Registered trials
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