ArticleCell reports2018
Olfactory Neurons and Brain Centers Directing Oviposition Decisions in Drosophila.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- Genetic manipulation technologies for precise cellular control: a comparative review of five approaches.Frontiers in bioengineering and biotechnology · 2026Review
- Differential modulation of feedforward inhibition reflects topographic organization in the olfactory system.Nature communications · 2025Article
- The TRP-channel painless mediates substrate stiffness sensing in the legs during Drosophila oviposition.PLoS genetics · 2025Article
- Gal4 drivers of the geosmin receptor Or56a exhibit ectopic expression in the labral sense organ of Drosophila.Scientific reports · 2025Article
- An integrated anatomical, functional and evolutionary view of the Drosophila olfactory system.EMBO reports · 2025Article
- An integrated anatomical, functional and evolutionary view of thebioRxiv : the preprint server for biology · 2025Article
- Targeted deletion of olfactory receptors inJournal of neurogenetics · 2024Article
- The egg-counter: a novel microfluidic platform for characterization ofLab on a chip · 2024Article
- An integrative sensor of body states: how the mushroom body modulates behavior depending on physiological context.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Input density tunes Kenyon cell sensory responses in the Drosophila mushroom body.Current biology : CB · 2023Article
- Odor-regulated oviposition behavior in an ecological specialist.Nature communications · 2023Article
- Hacking brain development to test models of sensory coding.bioRxiv : the preprint server for biology · 2023Article
- Synaptic Development in Diverse Olfactory Neuron Classes Uses Distinct Temporal and Activity-Related Programs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Review
- A dopamine-gated learning circuit underpins reproductive state-dependent odor preference ineLife · 2022Article
- Odorant-receptor-mediated regulation of chemosensory gene expression in the malaria mosquito Anopheles gambiae.Cell reports · 2022Article
- Evolution of Olfactory Receptors Tuned to Mustard Oils in Herbivorous Drosophilidae.Molecular biology and evolution · 2022Article
- Article
- Is the Natural Instinct to Oviposit in Mated Female Oriental Fruit Fly,Frontiers in physiology · 2022Article
- Neuropeptide F signaling regulates parasitoid-specific germline development and egg-laying in Drosophila.PLoS genetics · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The sense of smell influences many behaviors, yet how odors are represented in the brain remains unclear. A major challenge to studying olfaction is the lack of methods allowing activation of specific types of olfactory neurons in an ethologically relevant setting. To address this, we developed a genetic method in Drosophila called olfactogenetics in which a narrowly tuned odorant receptor, Or56a, is ectopically expressed in different olfactory neuron types. Stimulation with geosmin (the only known Or56a ligand) in an Or56a mutant background leads to specific activation of only target olfactory neuron types. We used this approach to identify olfactory sensory neurons (OSNs) that directly guide oviposition decisions. We identify 5 OSN-types (Or71a, Or47b, Or49a, Or67b, and Or7a) that, when activated alone, suppress oviposition. Projection neurons partnering with these OSNs share a region of innervation in the lateral horn, suggesting that oviposition site selection might be encoded in this brain region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.