Evidence map›Paper›PMID 30089259›Full record

ArticleCell reports2018

Homeodomain Proteins Directly Regulate ATM Kinase Activity.

Tanya E Johnson, Ji-Hoon Lee, Logan R Myler, Yi Zhou, Trenell J Mosley, Soo-Hyun Yang, Bio-Bricks for Molecular Machines FRI Stream, Nadima Uprety, Jonghwan Kim, Tanya T Paull

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Tanya E JohnsonDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA; Howard Hughes Medical Institute, The University of Texas at Austin, Austin, TX 78712, USA.
Ji-Hoon LeeDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA; Howard Hughes Medical Institute, The University of Texas at Austin, Austin, TX 78712, USA.
Logan R MylerDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA; Howard Hughes Medical Institute, The University of Texas at Austin, Austin, TX 78712, USA.
Yi ZhouDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Trenell J MosleyDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Soo-Hyun YangCollege of Natural Sciences, The University of Texas at Austin, Austin, TX 78712, USA.
Bio-Bricks for Molecular Machines FRI StreamCollege of Natural Sciences, The University of Texas at Austin, Austin, TX 78712, USA.
Nadima UpretyDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Jonghwan KimDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Tanya T PaullDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA; Howard Hughes Medical Institute, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address: tpaull@utexas.edu.
The University of Texas at Austin · USHoward Hughes Medical Institute · USEmory University · US

Funding

Single-Molecule Studies of Human DNA Double Strand Break RepairF99CA212452 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI MYLER, LOGAN ROSS · 2016 to 2017
$69k
Howard Hughes Medical InstituteNCI NIH HHS F99 CA212452
6 · The paper itself

Abstract

Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that coordinates the response to DNA double-strand breaks and oxidative stress. NKX3.1, a prostate-specific transcription factor, was recently shown to directly stimulate ATM kinase activity through its highly conserved homeodomain. Here, we show that other members of the homeodomain family can also regulate ATM kinase activity. We found that six representative homeodomain proteins (NKX3.1, NKX2.2, TTF1, NKX2.5, HOXB7, and CDX2) physically and functionally interact with ATM and with the Mre11-Rad50-Nbs1 (MRN) complex that activates ATM in combination with DNA double-strand breaks. The binding between homeodomain proteins and ATM stimulates oxidation-induced ATM activation in vitro but inhibits ATM kinase activity in the presence of MRN and DNA and in human cells. These findings suggest that many tissue-specific homeodomain proteins may regulate ATM activity during development and differentiation and that this is a unique mechanism for the control of the DNA damage response.

Indexed as

Ataxia Telangiectasia Mutated ProteinsHomeobox Protein Nkx-2.2Homeodomain ProteinsHumansNuclear ProteinsTranscription FactorsTransfectionAtaxia Telangiectasia Mutated ProteinsHomeobox Protein Nkx-2.2Homeodomain ProteinsNKX2-2 protein, humanNuclear ProteinsTranscription FactorsATMDNA damage responseDNA double-strand breakshomeodomain proteinsMRN

Identifiers

PMID30089259
PMCPMC6127865
OpenAlexW2887941209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.