ArticleBiophysical journal2018
Cooperative Contraction Behaviors of a One-Dimensional Cell Chain.
Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Nano-to-macroscale dual core-shell structured bioartificial ligament improves outcomes of anterior cruciate ligament reconstruction in rats: A proof-of-concept study.Bioactive materials · 2026Article
- Three-dimensional cellular dynamics and mandibular morphogenesis.Frontiers in cell and developmental biology · 2026Article
- Current strategies for enhancement of the bioactivity of artificial ligaments: A mini-review.Journal of orthopaedic translation · 2022Review
- Intercellular water exchanges trigger soliton-like waves in multicellular systems.Biophysical journal · 2022Article
- Carbon nanotube-reduced graphene oxide fiber with high torsional strength from rheological hierarchy control.Nature communications · 2021Article
- Sustained Oscillations of Epithelial Cell Sheets.Biophysical journal · 2019Article
- Tension- and Adhesion-Regulated Retraction of Injured Axons.Biophysical journal · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
Collective behaviors of multiple cells play important roles in various physiological and pathological processes, but the mechanisms of coordination among cells are highly unknown. Here, we build a one-dimensional cell-chain model to quantitatively study cell cooperativity. Combining experimental and theoretical approaches, we showed that the matrix stiffness, intercellular adhesion strength, and cell-chain length have a significant effect on the cooperative contraction of the cell chains. Cells have strong cooperativity, i.e., exhibiting a united contraction mode, in shorter cell chains or on softer matrix or with higher intercellular adhesion strength. In contrast, cells would exhibit a divided contraction when the cell chain was long or on stiffer matrix or with weaker adhesion strength. In addition, our quantitative results indicated that the cooperativity of cells is regulated by the coupling between matrix stiffness and intercellular adhesion, which can be quantified by an explicit parameter group. These results may provide guidelines for regulating the cooperativity of cells in their collective behaviors in tissue morphogenesis and tissue engineering in biomedical applications.
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