ArticleZebrafish2018
Delay of Initial Feeding of Zebrafish Larvae Until 8 Days Postfertilization Has No Impact on Survival or Growth Through the Juvenile Stage.
Article in Zebrafish, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 81 citations in OpenAlex.
- Gut and Glomerular Barriers Determine Nanoplastic Fate and Systemic Impact.ACS environmental Au · 2026Article
- Critical period plasticity enables credit assignment.bioRxiv : the preprint server for biology · 2026Article
- Carboxyl Surface Modification Attenuates Polystyrene- but Not Poly(methyl methacrylate) Nanoplastic-Induced Gut Dysbiosis in Zebrafish Larvae.Environment & health (Washington, D.C.) · 2026Article
- Dynamic expression of the zebrafish (Danio rerio) proteome across early larval development.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2025Article
- Macrophage/microglia-dependent mechanisms drive retinal pigment epithelium regeneration in zebrafish.Cell reports · 2025Article
- Effects of age on the response to spinal cord injury: optimizing the larval zebrafish model.Developmental biology · 2025Article
- Optogenetic activation of hypothalamic AgRP neurons in transgenic zebrafish larvae increased food intake.Scientific reports · 2025Article
- Large animal models for investigating the applications of photodynamic therapy.Zoological research · 2025Review
- Marigold: a machine learning-based web app for zebrafish pose tracking.BMC bioinformatics · 2025Article
- Interleukin-34 and debris clearance by mononuclear phagocytes drive retinal pigment epithelium regeneration in zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Article
- d-Amphetamine and Feeding States Cohesively Affect Locomotion and Motor Neuron Response in Zebrafish Larvae.Brain and behavior · 2024Article
- Deep autoencoder-based behavioral pattern recognition outperforms standard statistical methods in high-dimensional zebrafish studies.PLoS computational biology · 2024Article
- Rearing conditions (isolated versus group rearing) affect rotenone-induced changes in the behavior of zebrafish (Danio rerio) embryos in the coiling assay.Environmental science and pollution research international · 2024Article
- Exploring the Importance of Environmental Complexity for Newly Hatched Zebrafish.Animals : an open access journal from MDPI · 2024Article
- Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish.Pharmacological reports : PR · 2023Article
- Gonacin: A germ cell-derived hormone with glucogenic, orexigenic, and gonadal activities.iScience · 2023Article
- Apollo-NADPScience advances · 2023Article
- Excess glucose or fat differentially affects metabolism and appetite-related gene expression during zebrafish embryogenesis.iScience · 2023Article
- Optimizing assays of zebrafish larvae swimming performance for drug discovery.Expert opinion on drug discovery · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The use of early-stage zebrafish for biomedical research spans early organogenesis to free-swimming larva. A key benefit of this model organism is that repeated assessments spanning several days can be performed of individual larvae within a single experiment, often in conjunction with administered drugs. However, the initiation of feeding, typically at 5 days postfertilization (dpf), can make serial assessments challenging. Therefore, delayed feeding would increase the utility of the model. To ask whether feeding could be delayed without adversely affecting larval growth and development up to 39 dpf, we systematically raised zebrafish and introduced feeding at 5 dpf or delayed initial feeding up to 9 dpf. We assessed survival into the juvenile stage (39 dpf) and anterior-posterior length at this age as proxies for growth and development. Delaying feeding initiation up to 8 dpf did not decrease baseline survival of greater than 90%; survival decreased to 66% only when delayed to 9 dpf. Larval length was no different under any of these conditions. Our findings define 9 dpf as the critical age before which larval zebrafish must be fed when raising to 39 dpf. The option to delay feeding to 8 dpf will broaden experimental applications for the zebrafish larval model.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.