ArticlePloS one2018
Genome-wide association study using haplotype alleles for the evaluation of reproductive traits in Nelore cattle.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 17 citations in OpenAlex.
- Identification of candidate genes for reproductive traits in Chinese Holstein cattle using single-step genome-wide association study.Journal of animal science · 2026Article
- Genomic signatures of selection in drug metabolizing genes across cattle populations.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Genome-wide association studies and candidate genes networks affecting reproductive traits using Iranian Holstein sequence data.BMC genomics · 2025Article
- Integrative genomic analysis reveals shared loci for reproduction and production traits in Yorkshire pigs.BMC genomics · 2025Article
- Identification of genetic variants affecting reproduction traits in Vrindavani cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- Genome-Wide Association Study of Fiber Diameter in Alpacas.Animals : an open access journal from MDPI · 2023Article
- Genetic parameters for various semen production and quality traits and indicators of male and female reproductive performance in Nellore cattle.BMC genomics · 2023Article
- Circular RNA ame_circ_2015 Function as microRNA Sponges in Regulating Egg-Laying of Honeybees (Life (Basel, Switzerland) · 2023Article
- A Random Forest-Based Genome-Wide Scan Reveals Fertility-Related Candidate Genes and Potential Inter-Chromosomal Epistatic Regions Associated With Age at First Calving in Nellore Cattle.Frontiers in genetics · 2022Article
- Genome-Wide Association Study Provides Insights into Important Genes for Reproductive Traits in Nelore Cattle.Animals : an open access journal from MDPI · 2021Article
- Genetic Parameters and Genome-Wide Association Studies for Anti-Müllerian Hormone Levels and Antral Follicle Populations Measured After Estrus Synchronization in Nellore Cattle.Animals : an open access journal from MDPI · 2020Article
- Uncovering Sub-Structure and Genomic Profiles in Across-Countries Subpopulations of Angus Cattle.Scientific reports · 2020Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zebu cattle (Bos taurus indicus) are highly adapted to tropical regions. However, females reach puberty after taurine heifers, which affects the economic efficiency of beef cattle breeding in the tropical regions. The aims of this study were to establish associations between the haplotype alleles of the bovine genome and age at first calving (AFC) in the Nelore cattle, and to identify the genes and quantitative trait loci (QTL) related to this phenotype. A total of 2,273 Nelore cattle (995 males and 1,278 females) genotyped using the Illumina BovineHD BeadChip were used in the current study. The association analysis included females with valid first calving records as well as open heifers. Linkage disequilibrium (LD) analysis among the markers was performed using blocks of 5, 10, and 15 markers, which were determined by sliding windows shifting one marker at a time. Then, the haplotype block size to be used in the association study was chosen based on the highest r2 average among the SNPs in the block. The five HapAlleles most strongly associated with the trait (top five) were considered as significant associations. The results of the analysis revealed four genomic regions related to AFC, which overlapped with 20 QTL of the reproductive traits reported previously. Furthermore, there were 19 genes related to reproduction in those regions. In conclusion, the use of haplotypes allowed the detection of chromosomal regions associated with AFC in Nelore cattle, and provided the basis for elucidating the mechanisms underlying this trait.
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