ArticleMedical science monitor : international medical journal of experimental and clinical research2018
Effects of Different Cognitive Trainings on Amnestic Mild Cognitive Impairment in the Elderly: A One-Year Longitudinal Functional Magnetic Resonance Imaging (MRI) Study.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Comparative efficacy of cognitive training modalities in cognitive impairment: A systematic review and network meta-analysis.The journal of prevention of Alzheimer's disease · 2025Pooled it
- Effects of preventive interventions on neuroimaging biomarkers in subjects at-risk to develop Alzheimer's disease: A systematic review.Frontiers in aging neuroscience · 2022Pooled it
- Repetitive Transcranial Magnetic Stimulation for Improving Cognitive Function in Patients With Mild Cognitive Impairment: A Systematic Review.Frontiers in aging neuroscience · 2020Pooled it
- Long-term cognitive training enhances fluid cognition and brain connectivity in individuals with MCI.Translational psychiatry · 2024Trial
- Strengthening the Aging Brain: Functional Connectivity Changes After a Language-Based Cognitive Program.Brain sciences · 2025Article
- Functional brain activity in patients with amnestic mild cognitive impairment: an rs-fMRI study.Frontiers in neurology · 2023Article
- Cognitive Training Effect and Imaging Evidence.Advances in experimental medicine and biology · 2023Article
- Concurrent Structural and Functional Patterns in Patients With Amnestic Mild Cognitive Impairment.Frontiers in aging neuroscience · 2022Article
- Acupressure and Cognitive Training Can Improve Cognitive Functions of Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial.Frontiers in psychology · 2021Article
- Outcomes tested in non-pharmacological interventions in mild cognitive impairment and mild dementia: a scoping review.BMJ open · 2020Article
- An update on magnetic resonance imaging markers in AD.Therapeutic advances in neurological disorders · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Cognitive training has been focused on the interventions of amnestic mild cognitive impairment (aMCI) in recent years, with poor understanding. MATERIAL AND METHODS The study participants with aMCI were screened in a previous intervention trial. Functional magnetic resonance imaging (fMRI) was adopted to investigate effects of single-domain cognitive training (SDCT) and multi-domain cognitive training (MDCT) on aMCI and to explore potential mechanisms. RESULTS There were significant differences in the grey matter volume of the middle frontal gyrus, superior parietal lobule, inferior temporal gyrus, fusiform gyrus, and ventral V3 between the MDCT/SDCT group and the control group (P<0.05). Regional homogeneity (ReHo) increased significantly in the right and left inferior frontal gyrus as well as in the left and right precentral gyrus after intervention in the MDCT group and the SDCT group. ReHo increased significantly in the right and left lingual gyrus of the MDCT group and the control group. ReHo reduced significantly in the right middle temporal gyrus of the MDCT group but increased significantly in the left middle temporal gyrus in the SDCT group and the control group. The voxel of grey matter in the precuneus was positively related to the language scores on RBANS (Repeatable Battery for the Assessment of Neuropsychological Status), and amygdala, fusiform gyrus, and hippocampus also had a positive relationship with delayed memory scores in RBANS of the MDCT group. In the MDCT group, the attention and reasoning scores were also positively related to the ReHo of middle temporal gyrus. CONCLUSIONS Both MDCT and SDCT may improve the aMCI at brain functional and structural levels; however, the MDCT group exhibited higher ReHo values in middle temporal gyrus and superior occipital gyrus. Also, it was confirmed that MDCT leads to better results than SDCT, showing a significant correlation of cognitive functions such as attention, memory, reasoning, and visual-spatial ability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.