Evidence map›Paper›PMID 30088834›Full record

Trial reportDepression and anxiety2018

Mindfulness-based cognitive therapy for patients with chronic, treatment-resistant depression: A pragmatic randomized controlled trial.

Mira B Cladder-Micus, Anne E M Speckens, Janna N Vrijsen, A Rogier T Donders, Eni S Becker, Jan Spijker

Registry-linked trialAbstract readPragmatic Clinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Depression and anxiety, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05831072 (Efficacy of Mindfulness-cognitive Oriented Group Intervention Program on Depressive Symptoms, Coping Strategies and Quality of Life in University Students), which is not on this map. Cited by 57 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05831072 nacompletednot on this mapstarted 2023, after this paper: background citation

Efficacy of Mindfulness-cognitive Oriented Group Intervention Program on Depressive Symptoms, Coping Strategies and Quality of Life in University Students

TypeinterventionalSponsorChung Shan Medical UniversityRan2023 to 2023Enrolled19ConditionsDepression in AdolescenceArmsMindfulness-cognitive oriented group program
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mira B Cladder-MicusBehavioural Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.ORCID 0000-0003-4304-9202
Anne E M SpeckensDepartment of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Janna N VrijsenDepression Expertise Centre, Pro Persona Mental Health Care, Nijmegen, The Netherlands.ORCID 0000-0002-7081-9893
A Rogier T DondersDepartment for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
Eni S BeckerBehavioural Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
Jan SpijkerBehavioural Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.

Funding

Fonds Psychische Gezondheid 2011 6630
6 · The paper itself

Abstract

backgroundChronic and treatment-resistant depressions pose serious problems in mental health care. Mindfulness-based cognitive therapy (MBCT) is an effective treatment for remitted and currently depressed patients. It is, however, unknown whether MBCT is effective for chronic, treatment-resistant depressed patients.

methodA pragmatic, multicenter, randomized-controlled trial was conducted comparing treatment-as-usual (TAU) with MBCT + TAU in 106 chronically depressed outpatients who previously received pharmacotherapy (≥4 weeks) and psychological treatment (≥10 sessions).

resultsBased on the intention-to-treat (ITT) analysis, participants in the MBCT + TAU condition did not have significantly fewer depressive symptoms than those in the TAU condition (-3.23 [-6.99 to 0.54], d = 0.35, P = 0.09) at posttreatment. However, compared to TAU, the MBCT + TAU group reported significantly higher remission rates (χ

conclusionAlthough the ITT analysis did not reveal a significant reduction in depressive symptoms of MBCT + TAU over TAU, MBCT + TAU seems to have beneficial effects for chronic, treatment-resistant depressed patients in terms of remission rates, rumination, quality of life, mindfulness skills, and self-compassion. Additionally, patients who completed MBCT showed significant reductions in depressive symptoms. Reasons for non-completion should be further investigated.

Indexed as

AdultCognitive Behavioral TherapyDepressionDepressive Disorder, Treatment-ResistantFemaleHumansMaleMiddle AgedMindfulnessOutpatientsQuality of LifeTreatment Outcomedepressive disordermindfulnessquality of liferandomized controlled trialtreatment-resistant depression

Identifiers

PMID30088834
PMCPMC6175087

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.