ArticlePhysics in medicine and biology2018
Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit.
Article in Physics in medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Evaluation of radiation damage effects of low-energy Auger and conversion electrons emitted byScientific reports · 2026Article
- Radiation-induced double-strand breaks by internal ex vivo irradiation of lymphocytes: Validation of a Monte Carlo simulation model using GATE and Geant4-DNA.Zeitschrift fur medizinische Physik · 2025Article
- In silico analysis of radiation-induced double-strand breaks by internal ex vivo irradiation of lymphocytes for 45 alpha- and beta/gamma-emitting radionuclides.EJNMMI research · 2025Article
- A clustering tool for generating biological geometries for computational modeling in radiobiology.Physics in medicine and biology · 2024Article
- Effects of Differing Underlying Assumptions in In Silico Models on Predictions of DNA Damage and Repair.Radiation research · 2023Article
- Microdosimetric Analysis for Boron Neutron Capture Therapy via Monte Carlo Track Structure Simulation with Modified Lithium Cross-sections.Radiation physics and chemistry (Oxford, England : 1993) · 2023Article
- Prediction of DNA rejoining kinetics and cell survival after proton irradiation for V79 cells using Geant4-DNA.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2023Article
- Nano-scale simulation of neuronal damage by galactic cosmic rays.Physics in medicine and biology · 2022Article
- The OpenGATE ecosystem for Monte Carlo simulation in medical physics.Physics in medicine and biology · 2022Review
- Catalytic activity imperative for nanoparticle dose enhancement in photon and proton therapy.Nature communications · 2022Article
- Nanoscale Calculation of Proton-Induced DNA Damage Using a Chromatin Geometry Model with Geant4-DNA.International journal of molecular sciences · 2022Article
- Applications of nanodosimetry in particle therapy planning and beyond.Physics in medicine and biology · 2021Review
- Article
- The relation between microdosimetry and induction of direct damage to DNA by alpha particles.Physics in medicine and biology · 2021Article
- Challenges in the quantification approach to a radiation relevant adverse outcome pathway for lung cancer.International journal of radiation biology · 2021Article
- Multi-scale Monte Carlo simulations of gold nanoparticle-induced DNA damages for kilovoltage X-ray irradiation in a xenograft mouse model using TOPAS-nBio.Cancer nanotechnology · 2021Article
- A Mechanistic DNA Repair and Survival Model (Medras): Applications to Intrinsic Radiosensitivity, Relative Biological Effectiveness and Dose-Rate.Frontiers in oncology · 2021Article
- Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and subsequent repair using Geant4-DNA.Scientific reports · 2020Article
- LET-Dependent Intertrack Yields in Proton Irradiation at Ultra-High Dose Rates Relevant for FLASH Therapy.Radiation research · 2020Article
- Monte Carlo track-structure for the radionuclide Copper-64: characterization of S-values, nanodosimetry and quantification of direct damage to DNA.Physics in medicine and biology · 2020Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 4 countries.
Funding
Abstract
Computational simulations, such as Monte Carlo track structure simulations, offer a powerful tool for quantitatively investigating radiation interactions within cells. The modelling of the spatial distribution of energy deposition events as well as diffusion of chemical free radical species, within realistic biological geometries, can help provide a comprehensive understanding of the effects of radiation on cells. Track structure simulations, however, generally require advanced computing skills to implement. The TOPAS-nBio toolkit, an extension to TOPAS (TOol for PArticle Simulation), aims to provide users with a comprehensive framework for radiobiology simulations, without the need for advanced computing skills. This includes providing users with an extensive library of advanced, realistic, biological geometries ranging from the micrometer scale (e.g. cells and organelles) down to the nanometer scale (e.g. DNA molecules and proteins). Here we present the geometries available in TOPAS-nBio.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.