Evidence map›Paper›PMID 30088798›Full record

ArticleMolecular biology of the cell2018

The myosin light-chain kinase MLCK-1 relocalizes during Caenorhabditis elegans ovulation to promote actomyosin bundle assembly and drive contraction.

Charlotte A Kelley, Alison C E Wirshing, Ronen Zaidel-Bar, Erin J Cram

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. PES-8 is required for Cytoskeletal Organization and Contractility in thebioRxiv : the preprint server for biology · 2026
    Article
  2. Tensions on the actin cytoskeleton and apical cell junctions in thebioRxiv : the preprint server for biology · 2024
    Article
  3. Tensions on the actin cytoskeleton and apical cell junctions in theFrontiers in cell and developmental biology · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Regulation of Actin Dynamics in theJournal of developmental biology · 2019
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Charlotte A KelleyDepartment of Biology, Northeastern University, Boston, MA 02115.
Alison C E WirshingDepartment of Biology, Northeastern University, Boston, MA 02115.
Ronen Zaidel-BarDepartment of Cell and Developmental Biology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.
Erin J CramDepartment of Biology, Northeastern University, Boston, MA 02115.
Northeastern University · USTel Aviv University · IL

Funding

In vivo analysis of mechanotransductionR01GM110268 · NIGMS · NORTHEASTERN UNIVERSITY · PI CRAM, ERIN JEAN · 2014 to 2023
$2.8M
NIGMS NIH HHS R01 GM110268
6 · The paper itself

Abstract

We identify the Caenorhabditis elegans myosin light-chain kinase, MLCK-1, required for contraction of spermathecae. During contraction, MLCK-1 moves from the apical cell boundaries to the basal actomyosin bundles, where it stabilizes myosin downstream of calcium signaling. MLCK and ROCK act in distinct subsets of cells to coordinate the timing of contraction.

Indexed as

OvulationActomyosinAmino Acid SequenceAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsFemaleFertilityHumansMyosinsPhosphorylationStructural Homology, ProteinActomyosinCaenorhabditis elegans ProteinsMyosins

Identifiers

PMID30088798
PMCPMC6232974
OpenAlexW2800455293

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.