ArticleGenetics and molecular biology
Linkage disequilibrium levels and allele frequency distribution in Blanco Orejinegro and Romosinuano Creole cattle using medium density SNP chip data.
Article in Genetics and molecular biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Genomic relationships, diversity and admixture in the Lucerna breed of Colombia.Tropical animal health and production · 2026Article
- Genetic Diversity and Population Structure of Two Mexican Creole Cattle Populations.Animals : an open access journal from MDPI · 2026Article
- Genomic Characterization of Peruvian Creole Goats: Insights into Population Structure and Runs of Homozygosity.Animals : an open access journal from MDPI · 2025Article
- Genome-wide diversity, linkage disequilibrium, and admixture in the main Colombian Creole pig breeds.Tropical animal health and production · 2024Article
- Genomic diversity study of highly crossbred cattle population in a Low and Middle Tropical environment.Tropical animal health and production · 2024Article
- A chromosome-level reference genome and pangenome for barn swallow population genomics.Cell reports · 2023Article
- Genome properties of key oil palm (Elaeis guineensis Jacq.) breeding populations.Journal of applied genetics · 2022Article
- Genomic characterization of the nucleus for conservation of the Chino Santandereano breed using SNP markers.Tropical animal health and production · 2021Article
- Unraveling the Genetic Diversity and Population Structure of Bangladeshi Indigenous Cattle Populations Using 50K SNP Markers.Animals : an open access journal from MDPI · 2021Article
- Genetic Background and Inbreeding Depression in Romosinuano Cattle Breed in Mexico.Animals : an open access journal from MDPI · 2021Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The linkage disequilibrium (LD) between molecular markers affects the accuracy of genome-wide association studies and genomic selection application. High-density genotyping platforms allow identifying the genotype of thousands of single nucleotide polymorphisms (SNPs) distributed throughout the animal genomes, which increases the resolution of LD evaluations. This study evaluated the distribution of minor allele frequencies (MAF) and the level of LD in the Colombian Creole cattle breeds Blanco Orejinegro (BON) and Romosinuano (ROMO) using a medium density SNP panel (BovineSNP50K_v2). The LD decay in these breeds was lower than those reported for other taurine breeds, achieving optimal LD values (r2 ≥ 0.3) up to a distance of 70 kb in BON and 100 kb in ROMO, which is possibly associated with the conservation status of these cattle populations and their effective population size. The average MAF for both breeds was 0.27 ± 0.14 with a higher SNP proportion having high MAF values (≥ 0.3). The LD levels and distribution of allele frequencies found in this study suggest that it is possible to have adequate coverage throughout the genome of these breeds using the BovineSNP50K_v2, capturing the effect of most QTL related with productive traits, and ensuring an adequate prediction capacity in genomic analysis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.