SynthesisAnatolian journal of cardiology2018
Association between caspase recruitment domain-containing protein 8 rs2043211 polymorphism and cardiovascular disease susceptibility: A systematic review and meta-analysis.
Synthesis in Anatolian journal of cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- CARD8: A Novel Inflammasome Sensor with Well-Known Anti-Inflammatory and Anti-Apoptotic Activity.Cells · 2024Review
- Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil.BioMed research international · 2022Article
- SNP rs2043211 (p.C10X) in CARD8 Is Associated with Large-Artery Atherosclerosis Stroke in a Chinese Population.Journal of molecular neuroscience : MN · 2021Article
- Investigation of NF-κB-94ins/del ATTG and CARD8 (rs2043211) Gene Polymorphism in Acute Lymphoblastic Leukemia.Frontiers in endocrinology · 2019Article
- Caspase recruitment domain-containing protein 8 rs2043211 polymorphism and cardiovascular disease susceptibility.Anatolian journal of cardiology · 2018Article
- Author`s Reply.Anatolian journal of cardiology · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo verify the association between the caspase recruitment domain-containing protein 8 (CARD8) single nucleotide polymorphism rs2043211 in the CARD8 gene and cardiovascular diseases.
methodsA comprehensive search was conducted for related literature in the PubMed, Embase, Cochrane Library, Web of Science, Wanfang Data, and China National Knowledge Infrastructure databases. At last, Six eligible case-control studies were included in this meta-analysis. Crude odds ratios (ORs) and 95% confidence intervals (CI) were calculated to estimate the strength of the association between CARD8 rs2043211 polymorphisms and the susceptibility of cardiovascular diseases.
resultsFor the homozygous model, OR was 1.21 (1.08-1.36, I2=0.0%, Pheterogeneity=0.542). For the heterozygous model (AT vs. AA), OR was 1.20 (1.04-1.38, I2=57.2%, Pheterogeneity=0.039). For the dominant model, OR was 1.24 (1.14-1.34, I2=38.5%, Pheterogeneity=0.149). For the allele model, OR was 0.96 (0.77-1.20, I2=92.7%, Pheterogeneity=0.000). For the recessive model, OR was 1.00 (0.91-1.10, I2=48.4%, Pheterogeneity=0.085).
conclusionThe present study showed that CARD8 rs2043211 polymorphism is associated with cardiovascular diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.