ArticleThe Journal of international medical research2018
High 28-day mortality in critically ill patients with sepsis and concomitant active cancer.
Article in The Journal of international medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Pooled it
- All-cause mortality in cancer patients treated for sepsis in intensive care units: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- Gender-stratified analysis of sepsis mortality in cancer: a 45-year population-based cohort study.JNCI cancer spectrum · 2026Article
- Cannabis use disorder and severe sepsis outcomes in cancer patients: Insights from a national inpatient sample.World journal of critical care medicine · 2025Article
- Sepsis-related immune signature C3 in endometrial carcinoma: implications for prognosis, tumor progression through bioinformatics and experimental validation.Molecular biology reports · 2025Article
- Use of broad-spectrum antibiotics in adult cancer patients presenting to emergency department with non-neutropenic fever and/or suspected infection.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Interaction between post-tumor inflammation and vascular smooth muscle cell dysfunction in sepsis-induced cardiomyopathy.Frontiers in immunology · 2025Article
- Article
- Article
- Predictive value of peripheral blood indicators plus procalcitonin clearance rate for mortality in cancer patients with sepsis.American journal of cancer research · 2024Article
- Patients with cancer and sepsis trials: an unfair representation?Clinical medicine (London, England) · 2023Article
- Association between site of infection and mortality in patients with cancer with sepsis or septic shock: A retrospective cohort study.Experimental and therapeutic medicine · 2023Article
- Scoring systems in critically ill: Which one to use in cancer patients?World journal of critical care medicine · 2022Article
- Impact of cancer on mortality rates in patients with sepsis: A meta-analysis and meta-regression of current studies.World journal of clinical cases · 2022Article
- The Use of qSOFA, SOFA, and Ramathibodi Early Warning Score (REWS) to Predict Severe Complications in Hematologic Malignancy Patients.Open access emergency medicine : OAEM · 2022Article
- A 12-year study evaluating the outcomes and predictors of mortality in critically ill cancer patients admitted with septic shock.BMC cancer · 2021Article
- Sepsis-associated pathways segregate cancer groups.BMC cancer · 2020Article
- Prognostic accuracy of the sequential organ failure assessment (SOFA) and quick SOFA for mortality in cancer patients with sepsis defined by systemic inflammatory response syndrome (SIRS).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was performed to explore the characteristics and outcomes of patients with sepsis accompanied by active cancer who were admitted to the intensive care unit (ICU).
methodsThe baseline characteristics, infection profiles, and outcomes of patients with sepsis were retrospectively analyzed according to the presence of concomitant active cancer. The association between concomitant active cancer and 28-day mortality was explored.
resultsOf 23,956 patients with sepsis, 1574 (6.6%) had concomitant active cancer. The most common type was digestive (30.7%). The 28-day mortality ranged from 41.9% to 81.5%. Patients with active cancer had a significantly higher Simplified Acute Physiology Score II and significantly shorter length of ICU stay. Respiratory (32.9%), genitourinary (31.0%), and bloodstream (17.0%) infections were most common. Escherichia coli was the most frequent gram-negative pathogenic bacteria. The 28-day mortality rate was significantly higher in patients with than without active cancer. Concomitant active cancer was associated with increased 28-day mortality in patients with sepsis. Hematological malignancy was associated with a significantly higher risk of death than solid tumors.
conclusionsConcomitant active cancer was associated with higher 28-day mortality in patients with sepsis requiring ICU admission. Hematological malignancy was associated with a higher risk of death than solid tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.