ArticleAllergy, asthma & immunology research2018
Effects of Antibiotics on the Development of Asthma and Other Allergic Diseases in Children and Adolescents.
Article in Allergy, asthma & immunology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Butyrylated Starch Attenuates Antibiotic-Exacerbated Allergic Rhinitis by Restoring the Gut Microbiota and Barrier Function in Mice.Food science & nutrition · 2026Article
- Trajectories of antibiotic prescriptions in Italian children in the first four years of life: a retrospective birth-cohort study.BMC public health · 2026Article
- Early life gut microbiome and its impact on childhood health and chronic conditions.Gut microbes · 2025Review
- Helicobacter pylori infection is associated with an increased risk of chronic obstructive pulmonary disease and asthma.Gut pathogens · 2025Article
- Broad-Spectrum Antibiotic Use at the End of Life in Patients With Advanced Cancer.JAMA network open · 2025Observational
- Antibiotic-perturbed microbiota and the role of probiotics.Nature reviews. Gastroenterology & hepatology · 2025Review
- A review of pharmaceutical and personal care products and atopic dermatitis based on epidemiological and basic research findings.Frontiers in public health · 2025Review
- Understanding the role of the gut microbiome in solid tumor responses to immune checkpoint inhibitors for personalized therapeutic strategies: a review.Frontiers in immunology · 2024Review
- The gut-lung axis: the impact of the gut mycobiome on pulmonary diseases and infections.Oxford open immunology · 2024Review
- Effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants.Frontiers in microbiology · 2024Article
- Association between antibiotics and asthma risk among adults aged over 40 years: a nationally representative retrospective cohort study.BMJ open respiratory research · 2023Article
- Association between early life antibiotic exposure and development of early childhood atopic dermatitis.JAAD international · 2023Article
- Deciphering Differential Behavior of Immune Responses as the Foundation for Precision Dosing in Allergen Immunotherapy.Journal of personalized medicine · 2023Review
- Winds of change a tale of: asthma and microbiome.Frontiers in microbiology · 2023Review
- Atopic Dermatitis With Coexisting Food Allergy in Early Life Is Associated With Childhood Asthma.Allergy, asthma & immunology research · 2022Article
- Meta-analysis of early-life antibiotic use and allergic rhinitis.Open medicine (Warsaw, Poland) · 2022Article
- Nurturing the Early Life Gut Microbiome and Immune Maturation for Long Term Health.Microorganisms · 2021Review
- Article
- The role of the microbiome in gastrointestinal inflammation.Bioscience reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purposeOur aim was to explore whether antibiotic exposure in children and adolescents is associated with the later development of allergic diseases, using nationwide population-based claims data.
methodsWe collected information from the National Health Insurance Service (2006-2015) database. A total of 5,626,328 children and adolescents were eligible for the study. We explored whether exposure to antibiotics over the prior 7 years affects the later development of allergic diseases. We ran 3 analytical models after adjusting for confounding factors including age, sex, the number of visits to healthcare providers, income, and the place of residence (urban/rural).
resultsAllergic diseases were most common in male children and those aged < 10 years (atopic dermatitis, asthma and allergic rhinitis; all P < 0.01). Also, urban residents with higher incomes were more likely to develop allergic diseases (all P < 0.01). The annual number of days on which antibiotics were prescribed differed significantly between subjects with each allergic disease studied and a comparison group (all P < 0.01). Multiple logistic regression showed that as the duration of antibiotic exposure increased, the incidences of atopic dermatitis, asthma, and allergic rhinitis trended upward, even after adjusting for confounding factors (P for trend < 0.01).
conclusionsAntibiotic use early in life is associated with an increased risk of allergic disease, especially in young children; the risk increases as the duration of antibiotic therapy rises. Moreover, urban residence was more strongly associated with a longer duration of antibiotic use than was rural residence.
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Registered trials
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