Evidence map›Paper›PMID 30088217›Full record

Trial reportTranslational stroke research2019

Remote Limb Ischemic Conditioning and Motor Learning: Evaluation of Factors Influencing Response in Older Adults.

Ellen N Sutter, Anna E Mattlage, Marghuretta D Bland, Kendra M Cherry-Allen, Elinor Harrison, Swati M Surkar, Jeffrey M Gidday, Ling Chen, Tamara Hershey, Jin-Moo Lee and 1 more

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Translational stroke research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04598711 nacompletednot on this mapstarted 2021, after this paper: background citation

Effects of Remote Limb Ischemic Conditioning to Enhance Muscle Power, Dynamic Balance, and Walking Performance in Children With Cerebral Palsy

TypeinterventionalSponsorEast Carolina UniversityRan2021 to 2022Enrolled24ConditionsCerebral PalsyArmsRLIC, Sham Conditioning, Muscle Power training, Balance training, Treadmill Training
NCT05777070 nacompletednot on this mapstarted 2022, after this paper: background citation

Remote Ischemic Conditioning Combined With Bimanual Task Training to Enhance Bimanual Skill Learning and Corticospinal Excitability in Children With Unilateral Cerebral Palsy

TypeinterventionalSponsorEast Carolina UniversityRan2022 to 2025Enrolled51ConditionsUnilateral Cerebral PalsyArmsBimanual Cup Stacking Training
NCT06293118 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Chronic Effect of Ischemic Conditioning on Motor Function, Cognitive Performance, and Immune System in Individuals With Parkinson's Disease

TypeinterventionalSponsorHospital Israelita Albert EinsteinRan2026 to 2028Enrolled34ConditionsParkinson DiseaseArmsIschemic conditioning group, Sham group
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ellen N SutterProgram in Physical Therapy, Washington University School of Medicine, Campus Box 8502, 4444 Forest Park, Saint Louis, MO, 63108, USA.
Anna E MattlageProgram in Physical Therapy, Washington University School of Medicine, Campus Box 8502, 4444 Forest Park, Saint Louis, MO, 63108, USA.
Marghuretta D BlandProgram in Physical Therapy, Washington University School of Medicine, Campus Box 8502, 4444 Forest Park, Saint Louis, MO, 63108, USA.
Kendra M Cherry-AllenProgram in Physical Therapy, Washington University School of Medicine, Campus Box 8502, 4444 Forest Park, Saint Louis, MO, 63108, USA.
Elinor HarrisonProgram in Physical Therapy, Washington University School of Medicine, Campus Box 8502, 4444 Forest Park, Saint Louis, MO, 63108, USA.
Swati M SurkarProgram in Physical Therapy, Washington University School of Medicine, Campus Box 8502, 4444 Forest Park, Saint Louis, MO, 63108, USA.
Jeffrey M GiddayLouisiana State University School of Medicine, New Orleans, LA, USA.
Ling ChenDivision of Biostatistics, Washington University School of Medicine, Campus Box 8502, 4444 Forest Park, Saint Louis, MO, 63108, USA.
Tamara HersheyDepartment of Psychiatry, Washington University School of Medicine, Campus Box 8502, 4444 Forest Park, Saint Louis, MO, 63108, USA.
Jin-Moo LeeDepartment of Neurology, Washington University School of Medicine, Campus Box 8502, 4444 Forest Park, Saint Louis, MO, 63108, USA.
Catherine E LangProgram in Physical Therapy, Washington University School of Medicine, Campus Box 8502, 4444 Forest Park, Saint Louis, MO, 63108, USA. langc@wustl.edu.

Funding

DOCTORAL TRAINING PROGRAM IN MOVEMENT SCIENCET32HD007434 · NICHD · WASHINGTON UNIVERSITY · PI Michael D Harris, Catherine Lang · 1993 to 2026
$4.2M
ISCHEMIC CONDITIONING AS A NEURORECOVERY AGENT FOR STROKER01HD085930 · NICHD · WASHINGTON UNIVERSITY · PI LANG, CATHERINE · 2016 to 2020
$1.7M
NICHD NIH HHS R01 HD085930NICHD NIH HHS T32 HD007434
6 · The paper itself

Abstract

Remote limb ischemic conditioning (RLIC) is a clinically feasible method of promoting tissue protection against subsequent ischemic insult. Recent findings from our lab demonstrated that RLIC robustly enhances motor learning in young, healthy humans. The next step is to determine which individuals would receive maximum benefit from RLIC before applying these findings to clinical rehabilitation populations such as stroke. Numerous factors, such as age, sex, body mass index (BMI), and cardiovascular comorbidities may influence the response. Sixty-nine participants aged 40-80 were randomized to receive either RLIC (n = 33) or sham (n = 36) conditioning. Participants underwent seven consecutive sessions consisting of RLIC or sham conditioning with a blood pressure cuff on the upper extremity and motor training on a stability platform balance task, with two follow-up sessions. Balance change (post-test-pre-test) was compared across participants, groups, and the factors of age, sex, BMI, and comorbidities. Participants in both groups improved their performance on the balance task from pre- to post-test. Overall balance change was independently associated with age and BMI. There was no difference in balance change between RLIC and Sham groups. However, RLIC significantly enhanced balance performance in participants with no comorbidities. Compared with our previous study in young adults, middle-aged and older adults demonstrated smaller improvements on the balance task. RLIC enhanced learning in middle-aged and older adults only in the absence of pre-defined comorbidities. RLIC may be a promising tool for enhancing motor recovery, but the accumulation of comorbidity with age may decrease its effectiveness.

Indexed as

AdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansIschemiaIschemic PreconditioningLearningMaleMiddle AgedMotor SkillsPostural BalanceUpper ExtremityCardiovascular diseaseComorbidityIschemic preconditioningPsychomotor performance

Identifiers

PMID30088217
PMCPMC6367068

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.