ArticleJournal of molecular neuroscience : MN2018
Alzheimer's Disease Risk Variant rs2373115 Regulates GAB2 and NARS2 Expression in Human Brain Tissues.
Article in Journal of molecular neuroscience : MN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application.Molecular neurodegeneration · 2022Pooled it
- Genetic association of BIN1 and GAB2 in Alzheimer's disease: A meta-analysis and systematic review.Geriatrics & gerontology international · 2021Pooled it
- Functional Annotation of Alzheimer's Disease-Associated SNPs Based on Three-Dimensional Chromatin Structure.International journal of molecular sciences · 2026Article
- Gab2 (Grb2-Associated Binder2) Plays a Crucial Role in Inflammatory Signaling and Endothelial Dysfunction.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- rs1990622 variant associates with Alzheimer's disease and regulates TMEM106B expression in human brain tissues.BMC medicine · 2021Article
- Genomic Variation Prediction: A Summary From Different Views.Frontiers in cell and developmental biology · 2021Review
- Article
- Computational identification of N6-methyladenosine sites in multiple tissues of mammals.Computational and structural biotechnology journal · 2020Article
- Melatonin and Melatonergic Influence on Neuronal Transcription Factors: Implications for the Development of Novel Therapies for Neurodegenerative Disorders.Current neuropharmacology · 2020Review
- Identification of Gingivitis-Related Genes Across Human Tissues Based on the Summary Mendelian Randomization.Frontiers in cell and developmental biology · 2020Article
- Selecting Essential MicroRNAs Using a Novel Voting Method.Molecular therapy. Nucleic acids · 2019Article
- Genetic and Expression Analysis of COPI Genes and Alzheimer's Disease Susceptibility.Frontiers in genetics · 2019Article
- Systematic Characterization of Circular RNA-Associated CeRNA Network Identified Novel circRNA Biomarkers in Alzheimer's Disease.Frontiers in bioengineering and biotechnology · 2019Article
- An Efficient Classifier for Alzheimer's Disease Genes Identification.Molecules (Basel, Switzerland) · 2018Article
- Functional Prediction of Chronic Kidney Disease Susceptibility Gene PRKAG2 by Comprehensively Bioinformatics Analysis.Frontiers in genetics · 2018Article
- Genetic Variants Associated With Neurodegenerative Diseases Regulate Gene Expression in Immune Cell CD14+ Monocytes.Frontiers in genetics · 2018Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Genetic association studies have identified significant association between the GAB2 rs2373115 variant and Alzheimer's disease (AD). However, it is unknown whether rs2373115 affects the regulation of nearby genes. Here, we evaluate the potential effect of rs2373115 on gene expression using multiple eQTL (expression quantitative trait loci) datasets from human brain tissues from the Mayo Clinic brain expression genome-wide association study (eGWAS), the UK Brain Expression Consortium (UKBEC), the Genotype-Tissue Expression (GTEx) project, and the Brain xQTL Serve. Our findings indicate that the rs2373115 C allele is associated with increased NARS2 expression, and both reduced and increased GAB2 expression in human tissues. Using a large-scale AD case-control expression dataset, we found increased GAB2 expression and reduced NARS2 expression in AD cases compared with controls. We believe that our findings provide important information regarding the rs2373115 variant and expression of nearby genes with respect to AD risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.