ArticleNeuroscience bulletin2018
Separate Neural Networks for Gains and Losses in Intertemporal Choice.
Article in Neuroscience bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Time and amount attributes exert distinct neural influences on gain and loss evaluation.Social cognitive and affective neuroscience · 2026Article
- Sense of agency and decision making.Frontiers in psychology · 2026Article
- The computational and neural substrates of individual differences in impulsivity under loss framework.Human brain mapping · 2024Article
- Impact of self-control and time perception on intertemporal choices in gain and loss situations.Frontiers in psychology · 2023Article
- A neuro-computational account of procrastination behavior.Nature communications · 2022Article
- Reduced sensitivity to delayed time and delayed reward of the post-operative insular glioma patients in delay discounting.NeuroImage. Clinical · 2022Article
- Comparing Discounting of Potentially Real Rewards and Losses by Means of Functional Magnetic Resonance Imaging.Frontiers in systems neuroscience · 2022Article
- The effect of incentives on intertemporal choice: Choice, confidence, and eye movements.Frontiers in psychology · 2022Article
- The effects of materialism and ego depletion on intertemporal choice: An event-related potential study.Frontiers in psychology · 2022Article
- The Decision Strategies of Adolescents with Different Emotional Stabilities in Unfair Situations.Neuroscience bulletin · 2021Article
- Hierarchical Neural Prediction of Interpersonal Trust.Neuroscience bulletin · 2021Article
- Brain-wide Mapping of Mono-synaptic Afferents to Different Cell Types in the Laterodorsal Tegmentum.Neuroscience bulletin · 2019Article
- Modulation of Beta Oscillations for Implicit Motor Timing in Primate Sensorimotor Cortex during Movement Preparation.Neuroscience bulletin · 2019Article
- Neurobiology and clinical features of impulse control failure in Parkinson's disease.Neurological research and practice · 2019Review
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Authors and funding
8 authors.
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Abstract
An important and unresolved question is how human brain regions process information and interact with each other in intertemporal choice related to gains and losses. Using psychophysiological interaction and dynamic causal modeling analyses, we investigated the functional interactions between regions involved in the decision-making process while participants performed temporal discounting tasks in both the gains and losses domains. We found two distinct intrinsic valuation systems underlying temporal discounting in the gains and losses domains: gains were specifically evaluated in the medial regions, including the medial prefrontal and orbitofrontal cortices, and losses were evaluated in the lateral dorsolateral prefrontal cortex. In addition, immediate reward or punishment was found to modulate the functional interactions between the dorsolateral prefrontal cortex and distinct regions in both the gains and losses domains: in the gains domain, the mesolimbic regions; in the losses domain, the medial prefrontal cortex, anterior cingulate cortex, and insula. These findings suggest that intertemporal choice of gains and losses might involve distinct valuation systems, and more importantly, separate neural interactions may implement the intertemporal choices of gains and losses. These findings may provide a new biological perspective for understanding the neural mechanisms underlying intertemporal choice of gains and losses.
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