Evidence map›Paper›PMID 30088103›Full record

ReviewBiomedical microdevices2018

Multiplexed microarrays based on optically encoded microbeads.

Atieh Vafajoo, Azin Rostami, Sanam Foroutan Parsa, Reza Salarian, Navid Rabiee, Ghazal Rabiee, Mohammad Rabiee, Mohammadreza Tahriri, Daryoosh Vashaee, Lobat Tayebi and 1 more

Abstract readReview
In one paragraph

Review in Biomedical microdevices, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Atieh VafajooBiomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
Azin RostamiBiomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
Sanam Foroutan ParsaBiomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
Reza SalarianBiomedical Engineering Department, Maziar University, Royan, Noor, Iran.
Navid RabieeDepartment of Chemistry, Shahid Beheshti University, Tehran, Iran.
Ghazal RabieeDepartment of Chemistry, Shahid Beheshti University, Tehran, Iran.
Mohammad RabieeBiomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
Mohammadreza TahririMarquette University School of Dentistry, Milwaukee, WI, 53233, USA. mohammadreza.tahriri@marquette.edu.
Daryoosh VashaeeElectrical and Computer Engineering Department, North Carolina State University, Raleigh, NC, 27606, USA.
Lobat TayebiMarquette University School of Dentistry, Milwaukee, WI, 53233, USA.
Michael R HamblinWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114, USA. hamblin@helix.mgh.harvard.edu.ORCID 0000-0001-6431-4605

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
Synergistic Photodynamic Therapy for Catherer-Associated Urinary Tract InfectionsR21AI121700 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2016 to 2017
$462k
National Institute of Allergy and Infectious Diseases R01AI050875NIAID NIH HHS R01 AI050875NIAID NIH HHS R21 AI121700
6 · The paper itself

Abstract

In recent years, there has been growing interest in optically-encoded or tagged functionalized microbeads as a solid support platform to capture proteins or nucleotides which may serve as biomarkers of various diseases. Multiplexing technologies (suspension array or planar array) based on optically encoded microspheres have made possible the observation of relatively minor changes in biomarkers related to specific diseases. The ability to identify these changes at an early stage may allow the diagnosis of serious diseases (e.g. cancer) at a time-point when curative treatment may still be possible. As the overall accuracy of current diagnostic methods for some diseases is often disappointing, multiplexed assays based on optically encoded microbeads could play an important role to detect biomarkers of diseases in a non-invasive and accurate manner. However, detection systems based on functionalized encoded microbeads are still an emerging technology, and more research needs to be done in the future. This review paper is a preliminary attempt to summarize the state-of-the-art concerning diagnostic microbeads; including microsphere composition, synthesis, encoding technology, detection systems, and applications.

Indexed as

Microarray AnalysisMicrospheresCell Line, TumorComputer SimulationFlow CytometryFluorescent DyesHumansNanoparticlesNeoplasmsOptical PhenomenaPolymerizationProteinsSurface PropertiesFluorescent DyesProteinsEarly diagnosisMicrobeadsMultiplexing technologiesOptical encoding

Identifiers

PMID30088103
PMCPMC6143764

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.